ArticleShock (Augusta, Ga.)2012
Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis.
Article in Shock (Augusta, Ga.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury.Journal of translational medicine · 2025Article
- Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review.Molecules (Basel, Switzerland) · 2022Review
- Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury.Molecular medicine reports · 2020Article
- Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis.Neurotoxicity research · 2018Article
- Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Article
- Adipose-derived stem cells attenuate pulmonary microvascular hyperpermeability after smoke inhalation.PloS one · 2017Article
- Article
- OXIDATIVE STRESS IN A RAT MODEL OF COTTON SMOKE INHALATION-INDUCED PULMONARY INJURY.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Article
- Plasma ATP is required for neutrophil activation in a mouse sepsis model.Shock (Augusta, Ga.) · 2014Article
- Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.Molecular aspects of medicine · 2013Review
- Adverse effects of hemorrhagic shock resuscitation with stored blood are ameliorated by inhaled nitric oxide in lambs*.Critical care medicine · 2013Article
- Major blunt trauma evokes selective upregulation of oxidative enzymes in circulating leukocytes.Shock (Augusta, Ga.) · 2013Article
- Ischemic preconditioning attenuates lipid peroxidation and apoptosis in the cecal ligation and puncture model of sepsis.Experimental and therapeutic medicine · 2013Article
- Sodium Hydrosulphide alleviates remote lung injury following limb traumatic injury in rats.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The formation of oxidative stress in the lung and activation of neutrophils are major determinants in the development of respiratory failure after acute lung injury and sepsis. However, the time changes of these pathogenic factors have not been sufficiently described. Twenty-four chronically instrumented sheep were subjected to cotton smoke inhalation injury and instillation of live Pseudomonas aeruginosa into both lungs. The sheep were euthanized at 4, 8, 12, 18, and 24 h after injury. Additional sheep received sham injury and were euthanized after 24 h. Pulmonary function was assessed by determination of oxygenation index and pulmonary shunt fraction. In addition, lung tissue was harvested at the respective time points for the measurement of malondialdehyde, interleukin 6, poly(ADP ribose), myeloperoxidase, and alveolar polymorphonuclear neutrophil score. The injury induced severe respiratory failure that was associated with an early increase in lipid peroxidation and interleukin 6 expression. The injury further led to an increase in poly(ADP ribose) activity that reached its peak at 12 h after injury and declined afterward. In addition, progressive increases in markers of neutrophil accumulation in the lung were observed. The peak of neutrophil accumulation in the lung was associated with a severe depletion of circulating neutrophils. The results from our model may enhance the understanding of the pathophysiological alterations after acute lung injury and sepsis and thus be useful in exploring therapeutic interventions directed at modifying the expression or activation of inflammatory mediators.
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