ArticleShock (Augusta, Ga.)2012
Obese patients show a depressed cytokine profile following severe blunt injury.
Article in Shock (Augusta, Ga.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients: a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Pooled it
- One size does not fit all in severe infection: obesity alters outcome, susceptibility, treatment, and inflammatory response.Critical care (London, England) · 2013Trial
- BMI is independently associated with ARDS, sepsis and multiorgan failure after major trauma-results of a high-volume retrospective observational cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Observational
- The Impact of Obesity on Critical Illnesses.Shock (Augusta, Ga.) · 2021Review
- Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex.Frontiers in immunology · 2021Article
- Utilization of silicon nanowire field-effect transistors for the detection of a cardiac biomarker, cardiac troponin I and their applications involving animal models.Scientific reports · 2020Article
- Score performance of SAPS 2 and SAPS 3 in combination with biomarkers IL-6, PCT or CRP.PloS one · 2020Article
- High fat diet-induced obesity increases myocardial injury and alters cardiac STAT3 signaling in mice after polymicrobial sepsis.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Obesity enhances sepsis-induced liver inflammation and injury in mice.Obesity (Silver Spring, Md.) · 2016Article
- OBESITY AND CRITICAL ILLNESS: INSIGHTS FROM ANIMAL MODELS.Shock (Augusta, Ga.) · 2016Review
- Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury.Surgical infections · 2015Article
- The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation?Critical care (London, England) · 2013Article
- Differences in resuscitation in morbidly obese burn patients may contribute to high mortality.Journal of burn care & research : official publication of the American Burn AssociationObservational
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
We hypothesized that severely injured obese patients would display increased concentrations of proinflammatory cytokines when compared with patients of normal body mass index (BMI) and that this would be associated with multiple organ failure (MOF). This was a retrospective review of prospectively collected data in the "Inflammation and the Host Response to Injury" trauma-related database. Data were collected prospectively from US level I trauma centers. The subjects were severely injured adult blunt trauma patients. Cytokine concentrations obtained within 12 h of injury and on days 1 and 4 were compared between subjects on the basis of BMI (normal, 18.5-24.9 kg/m, and obese, ≥30 kg/m). Demographic measures, injury severity, cytokine concentrations, and outcome measures were compared between groups. Seventy-four adult blunt trauma victims were evaluated. Relative to patients of normal BMI (n = 34), obese patients (n = 40) demonstrated an overall depressed cytokine response to severe injury, with significantly lower concentrations of several cytokines. Obese patients showed greater incidences of nosocomial infection (60 vs. 45%, not statistically significant) and MOF (63% vs. 44%, not statistically significant) and a later onset of maximum MOF score (5 vs. 3 days, P < 0.04) when compared with those of normal BMI. Despite prior reports suggesting a proinflammatory cytokine profile in obese individuals, obese patients sustaining severe injury show a depressed early cytokine response when compared with patients of normal BMI. This may confer increased susceptibility to nosocomial infection and later MOF. Further study of immune dysfunction in the postinjury obese patient should assess the possibility of early immune suppression.
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