Evidence map›Paper›PMID 22266948›Full record

ArticleExperimental physiology2012

Vascular health in the ageing athlete.

Allison E DeVan, Douglas R Seals

Open access · bronzeAbstract read
In one paragraph

Article in Experimental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this map
    Review
  13. Article
  14. Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Article
  15. Article
  16. Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation.American journal of physiology. Heart and circulatory physiology · 2015
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Allison E DeVanDepartment of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO 80309, USA.
Douglas R Seals
University of Colorado Boulder · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
Human Aging, Exercise &FMD: Translational PhysiologyR37AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 2004 to 2013
$3.0M
NCRR NIH HHS UL1 RR025780NIA NIH HHS R37 AG013038NIA NIH HHS T32 AG000279
6 · The paper itself

Abstract

The demographics of ageing are changing dramatically such that there will be many more older adults in the near future. This setting is projected to produce a new 'boomer-driven' epidemic of physiological dysfunction, disability and risk of chronic degenerative disorders, including cardiovascular diseases. Standing out against this dreary biomedical forecast are Masters athletes, a group of middle-aged and older adults who engage in regular vigorous physical training and competitive sport. Compared with their sedentary/less active (untrained) peers, Masters athletes who perform endurance training-based activities demonstrate a more favourable arterial function-structure phenotype, including lower large elastic artery stiffness, enhanced vascular endothelial function and less arterial wall hypertrophy. As such, they may represent an exemplary model of healthy or 'successful' vascular ageing. In contrast, Masters athletes engaged primarily/exclusively in intensive resistance training exhibit less favourable arterial function-structure than their endurance-trained peers and, in some instances, untrained adults. These different arterial properties are probably explained in large part by the different intravascular mechanical forces generated during endurance versus resistance exercise-related training activities. The more favourable arterial function-structure profile of Masters endurance athletes may contribute to their low risk of clinical cardiovascular diseases.

Indexed as

AthletesAgingAthletic PerformanceBiomechanical PhenomenaBlood VesselsCardiovascular DiseasesElasticityEndothelium, VascularHumansRisk Factors

Identifiers

PMID22266948
PMCPMC3303941
OpenAlexW1498767146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.