ArticleClinical journal of the American Society of Nephrology : CJASN2012
Clinical course of 822 children with prenatally detected nephrouropathies.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Clinical significance and management of antenatally detected hydronephrosis due to ureteropelvic junction obstruction: a retrospective single-center study.BMC pediatrics · 2026Article
- Prognostic stratification in congenital abnormalities of the kidney and urinary tract: beyond the antenatal ultrasound.Childhood kidney diseases · 2026Article
- Follow-up of congenital abnormalities of the kidney and urinary tract from the antenatal period to the first year of life: a retrospective study from Turkey.Childhood kidney diseases · 2025Article
- Assessing masked hypertension and ambulatory arterial stiffness index in children congenital kidney malformations.Clinical and experimental nephrology · 2025Article
- Kidney function and transplants in prune belly syndrome: a scoping review.Pediatric nephrology (Berlin, Germany) · 2024Article
- Early predictive factors for progression to kidney failure in infants with severe congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Radiological and surgical correlation of pelviureteric junction obstruction in positional anomalies of the kidney in children.Pediatric radiology · 2023Article
- Evaluation of insertion/deletion (I/D) polymorphisms of ACE gene and circulating levels of angiotensin II in congenital anomalies of the kidney and urinary tract.Molecular biology reports · 2022Article
- Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Potential benefits of functional magnetic resonance urography (fMRU) over MAG3 renal scan in children with obstructive uropathy.Journal of pediatric urology · 2021Article
- Management of antenatal hydronephrosis.Pediatric nephrology (Berlin, Germany) · 2020Review
- A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis.Clinical kidney journal · 2020Article
- Editorial: Developmental Disorders of the Kidney and Urinary Tract: Recent Insights From Clinical and Molecular Studies.Frontiers in pediatrics · 2020Article
- A clinical predictive model of chronic kidney disease in children with posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2019Article
- A Predictive Model of Postnatal Surgical Intervention in Children With Prenatally Detected Congenital Anomalies of the Kidney and Urinary Tract.Frontiers in pediatrics · 2019Article
- Outcome after prenatal diagnosis of fetal urinary tract abnormalities: A tertiary center experienceJournal of the Turkish German Gynecological Association · 2018Article
- Severe congenital anomalies of the kidney and urinary tract: epidemiology can inform ethical decision-making.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Polymorphisms in α-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux.Journal of the American Society of Nephrology : JASN · 2016Article
- Outcome after prenatal diagnosis of congenital anomalies of the kidney and urinary tract.European journal of pediatrics · 2016Observational
- Genetics of Vesicoureteral Reflux.Current genomics · 2016Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWith the advent of fetal screening ultrasonography, the detection of congenital anomalies of the kidney and urinary tract (CAKUT) in utero has permitted early management of these conditions. This study aims to describe the clinical course of a large cohort of patients with prenatally detected nephrouropathies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this retrospective cohort study, 822 patients were prenatally diagnosed with CAKUT and systematically followed up at a tertiary Renal Unit for a median time of 43 months. Variables included in the analysis were sex, laterality, fetal ultrasonography (isolated versus associated hydronephrosis), and presence/absence of nephrouropathies. The events of interest were urinary tract infection, surgical interventions, hypertension, CKD, and death. Survival analyses were performed to evaluate time until occurrence of the events of interest.
resultsUrinary tract infection occurred in 245 (29.8%) children, with higher risk in females (hazard ratio=1.30, 95% confidence interval=1.02-1.70, P=0.05); 22 patients (2.7%) had hypertension, and 49 (6%) patients developed CKD. The risk of CKD was greater in patients with associated hydronephrosis (hazard ratio=5.20, 95% confidence interval=2.90-9.30, P<0.001). Twelve patients (1.5%) died during follow-up. Death was significantly associated with being born during the first period of the study (hazard ratio=6.00, 95% confidence interval=1.60-22.50, P<0.001), associated hydronephrosis (hazard ratio=9.30, 95% confidence interval=2.90-29.30, P<0.001), and CKD (hazard ratio=170.00, 95% confidence interval=41.00-228.00, P<0.001).
conclusionsIn our series, the clinical course of prenatally detected CAKUT was heterogeneous, and those infants with associated hydronephrosis at baseline were identified as a high-risk subgroup.
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