ArticleBehavioural brain research2012
Animated bird silhouette above the tank: acute alcohol diminishes fear responses in zebrafish.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
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- Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects.Frontiers in behavioral neuroscience · 2021Review
- Neural and endocrine responses to social stress differ during actual and virtual aggressive interactions or physiological sign stimuli.Behavioural processes · 2021Article
- Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish.Behavioural brain research · 2020Article
- Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring.PloS one · 2020Article
- Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task.Behavioural brain research · 2015Article
- Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery.Frontiers in behavioral neuroscience · 2015Article
- I'll take the low road: the evolutionary underpinnings of visually triggered fear.Frontiers in neuroscience · 2015Review
- Recent advances with a novel model organism: alcohol tolerance and sensitization in zebrafish (Danio rerio).Progress in neuro-psychopharmacology & biological psychiatry · 2014Review
- Induction of social behavior in zebrafish: live versus computer animated fish as stimuli.Zebrafish · 2014Article
- Zebrafish models for translational neuroscience research: from tank to bedside.Trends in neurosciences · 2014Review
- Zebrafish--on the move towards ophthalmological research.Eye (London, England) · 2014Review
- Acute ethanol exposure induces behavioural differences in two zebrafish (Danio rerio) strains: a time course analysis.Behavioural brain research · 2014Article
- Individual differences in activity levels in zebrafish (Danio rerio).Behavioural brain research · 2013Article
- Time-course of behavioural changes induced by ethanol in zebrafish (Danio rerio).Behavioural brain research · 2013Article
- A robotics-based behavioral paradigm to measure anxiety-related responses in zebrafish.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol dependence and alcohol abuse represent major unmet medical needs. The zebrafish is considered to be a promising vertebrate species with which the effects of alcohol on brain function and behavior and the mechanisms underlying these effects may be studied. Alcohol is known to induce alterations in motor function as well as fear and anxiety. Here we utilize a recently developed fear paradigm in which we employ an animated (moving) image of a bird silhouette. We measure the effect of acute alcohol administration (dose range employed: 0.00-0.75 vol/vol percentage, bath exposure for 60 min) on the behavioral responses of zebrafish. We test these responses during a pre-stimulus, stimulus and post-stimulus period of the task using both a video-tracking and an observation based quantification method. The fear inducing stimulus was found to decrease the distance of the zebrafish from the bottom of the tank, to increase number of erratic movements, and to increase the number of jumps in alcohol exposed fish (versus control fish). Alcohol attenuated these fear responses in a dose dependent manner. In addition, alcohol decreased general activity at the highest dose, an effect that was independent of the presentation of the stimulus. We discuss the similarities and differences between observation and video-tracking based results and conclude that fear paradigms will be useful in revealing alcohol induced functional changes in the brain of zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.