ReviewThe international journal of biochemistry & cell biology2012
D-Serine: a key to synaptic plasticity?
Review in The international journal of biochemistry & cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics.Biomolecules · 2022Pooled it
- The Astroglia Syncytial Theory of Consciousness.International journal of molecular sciences · 2025Review
- Racemization in Post-Translational Modifications Relevance to Protein Aging, Aggregation and Neurodegeneration: Tip of the Iceberg.Symmetry · 2021Article
- Astroglial changes in the zona incerta in response to motor cortex stimulation in a rat model of chronic neuropathy.Scientific reports · 2020Article
- Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection.Biosensors · 2018Article
- Astrocytic Atrophy FollowingFrontiers in molecular neuroscience · 2018Article
- Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging.Frontiers in molecular biosciences · 2018Review
- Taurine as an Essential Neuromodulator during Perinatal Cortical Development.Frontiers in cellular neuroscience · 2017Review
- Moss Chloroplasts Are Surrounded by a Peptidoglycan Wall Containing D-Amino Acids.The Plant cell · 2016Article
- Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain.Frontiers in neuroscience · 2015Review
- Deep brain stimulation: are astrocytes a key driver behind the scene?CNS neuroscience & therapeutics · 2014Review
- TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- NMDA receptor activation: two targets for two co-agonists.Neurochemical research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Two discoveries have put D-serine in the spotlight of neuroscience. First, D-serine was detected in brain tissue at high levels. Second, it was found to act on the N-methyl-D-aspartate receptor (NMDAR). This receptor is central to use-dependent synaptic plasticity, the cellular process which is widely believed to underlie learning. The ensuing quest for the mechanisms of D-serine synthesis, release and clearance, as well as for its physiological significance has provided a wealth of experimental evidence implicating D-serine in synaptic plasticity. However some key questions remain unanswered. Which cells release D-serine and upon what stimuli? Is D-serine supply dynamically regulated? What is the fate of released D-serine? Answering these questions appears to be an essential step in our understanding of how NMDARs trigger synaptic plasticity and learning. This review will highlight some recent advances and avenues of enquiry in dynamic D-serine signaling in the mammalian brain with emphasis on neurophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.