ArticleJournal of lipid research2012
Comparative study of serine-plasmalogens in human retina and optic nerve: identification of atypical species with odd carbon chains.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- The roles of glycerophospholipids in the aging retina and age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Serine ether glycerophospholipids: Decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Plasmalogens Regulate Retinal Connexin 43 Expression and Müller Glial Cells Gap Junction Intercellular Communication and Migration.Frontiers in cell and developmental biology · 2022Article
- Ether Lipids in Obesity: From Cells to Population Studies.Frontiers in physiology · 2022Review
- An overview of lipidomics utilizing cadaver derived biological samples.Expert review of proteomics · 2021Article
- Identification of unusual phospholipids from bovine heart mitochondria by HPLC-MS/MS.Journal of lipid research · 2020Article
- Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids.Journal of lipid research · 2020Article
- Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine.Frontiers in cell and developmental biology · 2020Review
- Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease.Molecules (Basel, Switzerland) · 2015Review
- Phosphatidylserine in the brain: metabolism and function.Progress in lipid research · 2014Review
- Comparative phospholipid profiles of control and glaucomatous human trabecular meshwork.Investigative ophthalmology & visual science · 2013Article
- Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid.Journal of lipid research · 2013Article
- Sphingolipids and ceramides in human aqueous humor.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this work was to detect and identify phosphatidylserine plasmalogen species in human ocular neurons represented by the retina and the optic nerve. Plasmalogens (vinyl-ether bearing phospholipids) are commonly found in the forms of phosphatidylcholine and phosphatidylethanolamine in numerous mammalian cell types, including the retina. Although their biological functions are unclear, the alteration of cellular plasmalogen content has been associated with several human disorders such as rhizomelic chondrodysplasia punctata Type 2 and primary open-angle glaucoma. By using liquid chromatography coupled to high-resolution and tandem mass spectrometry, we have identified for the first time several species of phosphatidylserine plasmalogens, including atypical forms having moieties with odd numbers of carbons and unsaturation in sn-2 position. Structural elucidation of the potential phosphatidylserine ether linked species was pursued by performing MS(3) experiments, and three fragments are proposed as marker ions to deduce which fatty acid is linked as ether or ester on the glycerol backbone. Interpretation of the fragmentation patterns based on this scheme enabled the assignment of structures to the m/z values, thereby identifying the phosphatidylserine plasmalogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.