ArticleAutonomic neuroscience : basic & clinical2012
Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.
Article in Autonomic neuroscience : basic & clinical, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Article
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- Article
- Autonomic components of Complex Regional Pain Syndrome (CRPS) are favourably affected by Electrical Twitch-Obtaining Intramuscular Stimulation (ETOIMS): effects on blood pressure and heart rate.BMJ innovations · 2017Article
- Neurobiology of fibromyalgia and chronic widespread pain.Neuroscience · 2016Review
- Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices.Physiology & behavior · 2016Article
- Article
- Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats.Frontiers in physiology · 2016Article
- Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring.The Journal of nutrition · 2015Article
- Acupuncture Affects Autonomic and Endocrine but Not Behavioural Responses Induced by Startle in Horses.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effects of the Fourth Ventricle Compression in the Regulation of the Autonomic Nervous System: A Randomized Control Trial.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.Molecular pain · 2014Article
- Consistent interindividual increases or decreases in muscle sympathetic nerve activity during experimental muscle pain.Experimental brain research · 2014Article
- Fibromyalgia and sleep in animal models: a current overview and future directions.Current pain and headache reports · 2014Review
- Animal models of fibromyalgia.Arthritis research & therapy · 2013Review
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Fibromyalgia (FM) is characterized by chronic non-inflammatory widespread pain (CWP) and changes in sympathetic function. In attempt to elucidate the pathophysiological mechanisms of FM we used a well-established CWP animal model. We aimed to evaluate changes in cardiac autonomic balance and baroreflex function in response to CWP induction in rats. CWP was induced by two injections of acidic saline (pH 4.0, n=8) five days apart into the left gastrocnemius muscle. Control animals were injected twice with normal saline (pH 7.2, n=6). One day after the second injection of acidic saline or normal saline, the animals had pulse interval (PI) and systolic arterial pressure (SAP) variability, and spontaneous baroreflex sensitivity (BRS) evaluated. After induction of CWP, there was an increase of power in the low frequency (LF) band of PI spectrum (12.75 ± 1.04 nu), a decrease in the high frequency (HF) band (87.25 ± 1.04 nu) and an increase of LF/HF ratio (0.16 ± 0.01), when compared to control animals (7.83 ± 1.13 nu LF; 92.16 ± 1.13 nu HF; 0.08 ± 0.01 LF/HF). In addition, there was an increase of power in the LF band of SAP spectrum (7.93 ± 1.39 mmHg(2)) when compared to control animals (2.97 ± 0.61 mmHg(2)). BRS was lower in acidic saline injected rats (0.59 ± 0.06 ms/mmHg) when compared to control animals (0.71 ± 0.03 ms/mmHg). Our results showed that induction of CWP in rats shifts cardiac sympathovagal balance towards sympathetic predominance and decreases BRS. These data corroborate findings in humans with FM.
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