ReviewNeuroscience and biobehavioral reviews2012
Sleep and obesity: a focus on animal models.
Review in Neuroscience and biobehavioral reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- Sleep disturbance, depression and pain in adults with sickle cell disease.BMC psychiatry · 2014Trial
- Methylphenidate leads to disruptions in rest/wake patterns after discontinuation.Psychopharmacology · 2026Article
- Association between fish consumption and sleep disorders among Chinese adults: a cross-sectional study.Annals of medicine · 2025Article
- Syndecan-4 as a genetic determinant of the metabolic syndrome.Diabetology & metabolic syndrome · 2023Article
- Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila.Cell discovery · 2023Article
- Connecting insufficient sleep and insomnia with metabolic dysfunction.Annals of the New York Academy of Sciences · 2023Review
- Contrasting effects of sleep fragmentation and angiotensin-II treatment upon pro-inflammatory responses of mice.Scientific reports · 2022Article
- Article
- The cyclic interaction between daytime behavior and the sleep behavior of laboratory dogs.Scientific reports · 2022Article
- Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats.Frontiers in neuroscience · 2022Article
- Validation of the Thyrotoxicosis-associated Insomnia Model Induced by Thyroxine through Sympathetic Stimulation: Face, Construct and Predictive Perspectives.Experimental neurobiology · 2021Article
- Article
- Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs.Diabetologia · 2020Article
- Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Article
- The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation.BMC complementary and alternative medicine · 2017Article
- Obesity and hypertension.Experimental and therapeutic medicine · 2016Article
- Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2016Article
- Article
- Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The rapid rise in obesity prevalence in the modern world parallels a significant reduction in restorative sleep (Agras et al., 2004; Dixon et al., 2007, 2001; Gangwisch and Heymsfield, 2004; Gupta et al., 2002; Sekine et al., 2002; Vioque et al., 2000; Wolk et al., 2003). Reduced sleep time and quality increases the risk for obesity, but the underlying mechanisms remain unclear (Gangwisch et al., 2005; Hicks et al., 1986; Imaki et al., 2002; Jennings et al., 2007; Moreno et al., 2006). A majority of the theories linking human sleep disturbances and obesity rely on self-reported sleep. However, studies with objective measurements of sleep/wake parameters suggest a U-shaped relationship between sleep and obesity. Studies in animal models are needed to improve our understanding of the association between sleep disturbances and obesity. Genetic and experimenter-induced models mimicking characteristics of human obesity are now available and these animal models will be useful in understanding whether sleep disturbances determine propensity for obesity, or result from obesity. These models exhibit weight gain profiles consistently different from control animals. Thus a careful evaluation of animal models will provide insight into the relationship between sleep disturbances and obesity in humans. In this review we first briefly consider the fundamentals of sleep and key sleep disturbances, such as sleep fragmentation and excessive daytime sleepiness (EDS), observed in obese individuals. Then we consider sleep deprivation studies and the role of circadian alterations in obesity. We describe sleep/wake changes in various rodent models of obesity and obesity resistance. Finally, we discuss possible mechanisms linking sleep disturbances with obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.