Evidence map›Paper›PMID 22266149›Full record

ArticleGastroenterology2012

Translational approaches for pharmacotherapy development for acute diarrhea.

Mark Donowitz, David H Alpers, Henry J Binder, Thomas Brewer, Jill Carrington, Michael J Grey

Open access · greenAbstract readConference Proceedings
In one paragraph

Article in Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.American journal of physiology. Gastrointestinal and liver physiology · 2017
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Secretory diarrhoea: mechanisms and emerging therapies.Nature reviews. Gastroenterology & hepatology · 2015
    Review
  19. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014
    Review
  20. An Adult Mouse Model ofPLoS neglected tropical diseases · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Mark DonowitzDepartment of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. mdonowit@jhmi.edu
David H Alpers
Henry J Binder
Thomas Brewer
Jill Carrington
Michael J Grey
National Institute of Diabetes and Digestive and Kidney Diseases · USBill & Melinda Gates Foundation · USJohns Hopkins University · USWashington University in St. Louis · USYale University · US

Funding

PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
NIDDK NIH HHS R01 DK061765
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Translational Research, BiomedicalAcute DiseaseAdministration, OralAnimalsAntidiarrhealsDiarrheaDisease Models, AnimalFluid TherapyHumansIntestinal MucosaIntestinesRehydration SolutionsRisk FactorsTreatment OutcomeAntidiarrhealsRehydration Solutions

Identifiers

PMID22266149
PMCPMC5881109
OpenAlexW2160411670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.