Evidence map›Paper›PMID 22265990›Full record

ReviewTrends in genetics : TIG2012

Human evolutionary genomics: ethical and interpretive issues.

Joseph J Vitti, Mildred K Cho, Sarah A Tishkoff, Pardis C Sabeti

Erratum issuedAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Personalised Medicine: The Odyssey from Hope to Practice.Journal of personalized medicine · 2018
    Review
  2. Bioethics, population studies, and geneticophobia.Journal of community genetics · 2015
    Article
  3. Article
  4. Ethical, legal, social, and policy implications of behavioral genetics.Annual review of genomics and human genetics · 2013
    Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors.

Joseph J VittiBroad Institute of MIT and Harvard, Cambridge, MA, USA. vitti@broadinstitute.org
Mildred K Cho
Sarah A Tishkoff
Pardis C Sabeti

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Genome-wide computational studies can now identify targets of natural selection. The unique information about humans these studies reveal, and the media attention they attract, indicate the need for caution and precision in communicating results. This need is exacerbated by ways in which evolutionary and genetic considerations have been misapplied to support discriminatory policies, by persistent misconceptions of these fields and by the social sensitivity surrounding discussions of racial ancestry. We discuss the foundations, accomplishments and future directions of human evolutionary genomics, attending to ways in which the interpretation of good science can go awry, and offer suggestions for researchers to prevent misapplication of their work.

Indexed as

BioethicsEvolution, MolecularGenome, HumanAnimalsGenomicsHumansSelection, Genetic

Identifiers

PMID22265990
PMCPMC5210170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.