Evidence map›Paper›PMID 22265568›Full record

ArticleTalanta2012

Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis.

Philip R Miller, Shelby A Skoog, Thayne L Edwards, Deanna M Lopez, David R Wheeler, Dulce C Arango, Xiaoyin Xiao, Susan M Brozik, Joseph Wang, Ronen Polsky and 1 more

Abstract read
In one paragraph

Article in Talanta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  19. Minimally Invasive Platforms in Biosensing.Frontiers in bioengineering and biotechnology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Philip R MillerJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, NC 27695-7115, USA.
Shelby A Skoog
Thayne L Edwards
Deanna M Lopez
David R Wheeler
Dulce C Arango
Xiaoyin Xiao
Susan M Brozik
Joseph Wang
Ronen Polsky
Roger J Narayan

Funding

Autonomous Treatment of Opioid AbuseR21DA026980 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NARAYAN, ROGER J · 2009 to 2010
$291k
NIDA NIH HHS R21 DA026980
6 · The paper itself

Abstract

The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure(®)) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period.

Indexed as

AcidosisBiosensing TechniquesCarbonCell AdhesionCoated Materials, BiocompatibleElectrochemical TechniquesExerciseGlucoseGlucose OxidaseHumansHydrogen-Ion ConcentrationLactic AcidMacrophagesMicroelectrodesNeedlesCarbonCoated Materials, BiocompatibleGlucoseGlucose OxidaseLactic Acid

Identifiers

PMID22265568
PMCPMC3266534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.