Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2012
Risperidone and divalproex differentially engage the fronto-striato-temporal circuitry in pediatric mania: a pharmacological functional magnetic resonance imaging study.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00176202 (Controlled Trial of Risperidone and Divalproex Sodium With MRI Assessment of Affected Circuitry in Pre and Post Treatment in Pediatric Bipolar), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Controlled Trial of Risperidone and Divalproex Sodium With MRI Assessment of Affected Circuitry in Pre and Post Treatment in Pediatric Bipolar
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Functional brain abnormalities of cognitive impairments in schizophrenia indicating higher integration of working memory than other domains.Molecular psychiatry · 2026Pooled it
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Conjoint and dissociated structural and functional abnormalities in first-episode drug-naive patients with major depressive disorder: a multimodal meta-analysis.Scientific reports · 2017Pooled it
- Pretreatment Alterations and Acute Medication Treatment Effects on Brain Task-Related Functional Connectivity in Youth With Bipolar Disorder: A Neuroimaging Randomized Clinical Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Trial
- Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacologyTrial
- Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.Frontiers in psychiatry · 2020Article
- Valproate for acute mania.The Cochrane database of systematic reviews · 2019Review
- A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel-based morphometry study.CNS neuroscience & therapeutics · 2018Article
- Schizophrenia symptom and functional correlates of anterior cingulate cortex activation to emotion stimuli: An fMRI investigation.Psychiatry research · 2015Article
- Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents.Journal of child and adolescent psychopharmacology · 2015Article
- Facial emotion recognition in childhood-onset bipolar I disorder: an evaluation of developmental differences between youths and adults.Bipolar disorders · 2015Article
- Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study.BMC psychiatry · 2014Article
- Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands.Psychological medicine · 2014Article
- Altered baseline brain activity in children with bipolar disorder during mania state: a resting-state study.Neuropsychiatric disease and treatment · 2014Article
- Negative emotion impairs working memory in pediatric patients with bipolar disorder type I.Psychological medicine · 2012Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder.Bipolar disorders · 2012Article
- Brain functional domains inform therapeutic interventions in attention-deficit/hyperactivity disorder and pediatric bipolar disorder.Expert review of neurotherapeutics · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe current study examined the impact of risperidone and divalproex on affective and working memory circuitry in patients with pediatric bipolar disorder (PBD).
methodThis was a six-week, double-blind, randomized trial of risperidone plus placebo versus divalproex plus placebo for patients with mania (n = 21; 13.6 ± 2.5 years of age). Functional magnetic resonance imaging (fMRI) outcomes were measured using a block design, affective, N-back task with angry, happy, and neutral face stimuli at baseline and at 6-week follow-up. Matched healthy controls (HC; n = 15, 14.5 ± 2.8 years) were also scanned twice.
resultsIn post hoc analyses on the significant interaction in a 3×2×2 analysis of variance (ANOVA) that included patient groups and HC, the risperidone group showed greater activation after treatment in response to the angry face condition in the left subgenual anterior cingulate cortex (ACC) and striatum relative to the divalproex group. The divalproex group showed greater activation relative to the risperidone group in the left inferior frontal gyrus and right middle temporal gyrus. Over the treatment course, the risperidone group showed greater change in activation in the left ventral striatum than the divalproex group, and the divalproex group showed greater activation change in left inferior frontal gyrus and right middle temporal gyrus than the risperidone group. Furthermore, each patient group showed increased activation relative to HC in fronto-striato-temporal regions over time. The happy face condition was potentially less emotionally challenging in this study and did not elicit notable findings.
conclusionsWhen patients performed a working memory task under emotional duress inherent in the paradigm, divalproex enhanced activation in a fronto-temporal circuit whereas risperidone increased activation in the dopamine (D₂) receptor-rich ventral striatum. Clinical trial registration information-Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar; http://www.clinicaltrials.gov; NCT00176202.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.