ReviewBest practice & research. Clinical rheumatology2011
Biomechanical factors in osteoarthritis.
Review in Best practice & research. Clinical rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
292 citing papers in PubMed, 4 syntheses or guidelines pooled it, 580 citations in OpenAlex.
- Objective Methods of Monitoring Usage of Orthotic Devices for the Extremities: A Systematic Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Association of low-grade inflammation caused by gut microbiota disturbances with osteoarthritis: A systematic review.Frontiers in veterinary science · 2022Pooled it
- Gut permeability and osteoarthritis, towards a mechanistic understanding of the pathogenesis: a systematic review.Annals of medicine · 2021Pooled it
- The relation between the gut microbiome and osteoarthritis: A systematic review of literature.PloS one · 2021Pooled it
- Effects of a two-week instrument-assisted soft tissue mobilization and exercise therapy versus sham and exercise on gait kinetics in moderate knee osteoarthritis: a randomized controlled trial.The Journal of manual & manipulative therapy · 2026Trial
- Direct anterior approachWorld journal of orthopedics · 2021Trial
- Complement Expression and Activation in Osteoarthritis Joint Compartments.Frontiers in immunology · 2020Trial
- A New Stress Test for Knee Joint Cartilage.Scientific reports · 2019Trial
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- Multimodal characterization of articular cartilage degeneration in the humeral head using Raman spectroscopy, biomechanics, and imaging.Osteoarthritis and cartilage · 2026Article
- Plasma proteomics mediate the association between degenerative joint diseases and dementia risk.Journal of advanced research · 2026Article
- Frequency and factors associated with neuropathic pain in patients with knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Article
- Central adiposity is associated with poorer functional capacity in women with knee osteoarthritis: a cross-sectional study with exploratory adjustment for pain intensity and radiographic severity.Rheumatology international · 2026Article
- Medial meniscus extrusion during gait identifies altered knee mechanical loading in early osteoarthritis of the knee.Journal of experimental orthopaedics · 2026Article
- Multiplanar Stability After Syndesmotic Screw Fixation vs Deltoid Ligament Repair in a Cadaveric Weber B/SER4b Ankle Fracture Model With Fibular Plate Fixation.Foot & ankle international · 2026Article
- The gut microbiome's role in the development and progression of post-traumatic osteoarthritis: A systematic review.Osteoarthritis and cartilage open · 2026Review
- Intra-articular injections of liposomal adenosine improve clinical outcomes and slow radiologic progression in a preclinical canine model of osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Article
- PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis.The Journal of biological chemistry · 2026Article
232 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint loading - associated to obesity, malalignment, trauma or joint instability - is a critical risk factor for joint degeneration, whereas exercise and weight loss have generally been shown to promote beneficial effects for osteoarthritic joints. The mechanisms by which mechanical stress alters the physiology or pathophysiology of articular cartilage or other joint tissues likely involve complex interactions with genetic and molecular influences, particularly local or systemic inflammation secondary to injury or obesity. Chondrocytes perceive physical signals from their environment using a variety of mechanisms, including ion channels, integrin-mediated connections to the extracellular matrix that involve membrane, cytoskeletal and intracellular deformation. An improved understanding of the biophysical and molecular pathways involved in chondrocyte mechanotransduction can provide insight into the development of novel therapeutic approaches for osteoarthritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.