Evidence map›Paper›PMID 22265148›Full record

ArticleAmerican journal of ophthalmology2012

Clinical features of newly diagnosed cytomegalovirus retinitis in northern Thailand.

Somsanguan Ausayakhun, Jeremy D Keenan, Sakarin Ausayakhun, Choeng Jirawison, Claire M Khouri, Alison H Skalet, David Heiden, Gary N Holland, Todd P Margolis

Abstract read
In one paragraph

Article in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Development of cytomegalovirus retinitis after negative conversion of cytomegalovirus antigenemia due to systemic antiviral therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  7. Observational
  8. Article
  9. Cytomegalovirus retinitis and HIV: Case reviews from KwaZulu-Natal Province, South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2017
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Somsanguan AusayakhunDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jeremy D Keenan
Sakarin Ausayakhun
Choeng Jirawison
Claire M Khouri
Alison H Skalet
David Heiden
Gary N Holland
Todd P Margolis

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Optimal trachoma control after mass antibiotic distributionsK23EY019071 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2008 to 2012
$982k
NCRR NIH HHS KL2 RR024130NEI NIH HHS K23 EY019071NEI NIH HHS K23EY019071
6 · The paper itself

Abstract

purposeTo characterize the clinical manifestations of cytomegalovirus (CMV) retinitis in northern Thailand.

designProspective, observational, cross-sectional study.

methodsWe recorded characteristics of 52 consecutive patients newly diagnosed with CMV retinitis at a tertiary university-based medical center in northern Thailand. Indirect ophthalmoscopy by experienced ophthalmologists was supplemented with fundus photography to determine the proportion of eyes with various clinical features of CMV retinitis.

resultsOf the 52 patients with CMV retinitis, 55.8% were female. All were HIV-positive. The vast majority (90.4%) had started antiretroviral therapy. CMV retinitis was bilateral in 46.2% of patients. Bilateral visual acuity worse than 20/60 was observed in 23.1% of patients. Of 76 eyes with CMV retinitis, 61.8% had zone I disease and 21.6% had lesions involving the fovea. Lesions larger than 25% of the retinal area were observed in 57.5% of affected eyes. CMV retinitis lesions commonly had marked or severe border opacity (47.4% of eyes). Vitreous haze often was present (46.1% of eyes). Visual impairment was more common in eyes with larger retinitis lesions. Retinitis lesion size, used as a proxy for duration of disease, was associated with fulminant appearance (odds ratio, 1.24; 95% confidence interval, 1.01 to 1.51) and marked or severe border opacity (odds ratio, 1.36; 95% confidence interval, 1.11 to 1.67). Based on lesion size, retinitis preceded antiretroviral treatment in each patient.

conclusionsPatients seeking treatment at a tertiary medical center in northern Thailand had advanced CMV retinitis, possibly because of delayed diagnosis. Earlier screening and treatment of CMV retinitis may limit progression of disease and may prevent visual impairment in this population.

Indexed as

Academic Medical CentersAdolescentAdultAIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsCross-Sectional StudiesCytomegalovirus RetinitisDelayed DiagnosisFemaleHIV SeropositivityHumansMaleMiddle AgedProspective StudiesThailandVision DisordersAnti-Retroviral Agents

Identifiers

PMID22265148
PMCPMC3331920

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.