ArticleClinical immunology (Orlando, Fla.)2012
Live attenuated influenza virus (LAIV) induces different mucosal T cell function in nonsmokers and smokers.
Article in Clinical immunology (Orlando, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Electronic-Cigarette Use Alters Nasal Mucosal Immune Response to Live-attenuated Influenza Virus. A Clinical Trial.American journal of respiratory cell and molecular biology · 2021Article
- Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches.Virology journal · 2020Review
- Immune Profile of the Nasal Mucosa in Patients with Cutaneous Leishmaniasis.Infection and immunity · 2020Article
- Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1.Frontiers in medicine · 2020Article
- Formation and Maintenance of Tissue Resident Memory CD8+ T Cells after Viral Infection.Pathogens (Basel, Switzerland) · 2019Review
- Emerging role of γδ T cells in vaccine-mediated protection from infectious diseases.Clinical & translational immunology · 2019Review
- Dynamic changes in lung responses after single and repeated exposures to cigarette smoke in mice.PloS one · 2019Article
- Protective role of γδ T cells in cigarette smoke and influenza infection.Mucosal immunology · 2018Article
- Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Racial/Ethnic Disparities in Influenza Vaccination of Chronically Ill US Adults: The Mediating Role of Perceived Discrimination in Health Care.Medical care · 2016Article
- Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.Frontiers in immunology · 2016Review
- Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Smoking association with influenza infection in renal transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2014Article
- Culturing of human nasal epithelial cells at the air liquid interface.Journal of visualized experiments : JoVE · 2013Article
- DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Epithelial cells, the "switchboard" of respiratory immune defense responses: effects of air pollutants.Swiss medical weekly · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Smokers are more susceptible to respiratory infections, including influenza. To explore the effect of smoking on influenza-induced responses within the nasal mucosa, we have developed a protocol using inoculation with live attenuated influenza virus (LAIV) vaccine followed by sampling of the nasal mucosa. Mucosal cell populations were harvested through superficial biopsy of the nasal inferior turbinate pre and post LAIV inoculation and analyzed using flow cytometry. The majority of nasal biopsy CD45+ immune cells at baseline were CD3+ T lymphocytes. Following LAIV, these lymphocytes increased in nonsmokers but not in smokers. A subset of individuals was negative for helper T cell marker CD4 and cytotoxic T cell marker CD8 but positive for the γδ T cell receptor (TCR). Increases in γδ TCR+ cells were greater in nonsmokers, than in smokers. Thus, LAIV-induced changes in CD3 T as well as γδ T lymphocyte percentages are suppressed in smokers compared to nonsmokers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.