Evidence map›Paper›PMID 22264040›Full record

ReviewCurrent HIV research2012

Mucosal transmission of human immunodeficiency virus.

Denis M Tebit, Nicaise Ndembi, Aaron Weinberg, Miguel E Quiñones-Mateu

Abstract readReview
In one paragraph

Review in Current HIV research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Exposure toVaccines · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. TheFuture virology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Denis M TebitDepartment of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-7288, USA.
Nicaise Ndembi
Aaron Weinberg
Miguel E Quiñones-Mateu

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Proj. 4-The Genetic Variation of Innate Immune Genes w/Oral Manifestations of HIVP01DE019759 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2009 to 2013
$9.0M
Ontogeny Of Oral Epithelial Antimicrobial PeptidesR01DE018276 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI WEINBERG, AARON · 2007 to 2015
$3.5M
Effects of drug resistance mutations on HIV replicative fitnessR21AI071747 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI QUINONES-MATEU, MIGUEL E · 2007 to 2008
$421k
NIAID NIH HHS AI-71747NIAID NIH HHS R21 AI071747NIDCR NIH HHS P01 DE019759NIDCR NIH HHS P01-DE019759NIDCR NIH HHS R01 DE018276NIDCR NIH HHS R01-DE018276
6 · The paper itself

Abstract

Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract (vaginal and cervical), as well as the rectal, penile, and oral mucosae have been extensively studied over the last thirty years towards a better understanding of--and to develop strategies to prevent--sexual HIV transmission. This review seeks to describe the biology of the events leading to HIV infection through the human mucosa and introduce some of the approaches attempted to prevent the sexual transmission of HIV.

Indexed as

Anti-Retroviral AgentsFemaleHIV InfectionsHumansImmunity, InnateImmunity, MucosalMaleMouth MucosaMucous MembranePenisRectumVaginaAnti-Retroviral Agents

Identifiers

PMID22264040
PMCPMC3744389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.