ArticleAIDS research and human retroviruses2012
Longitudinal assessment of pigtailed macaque lower genital tract microbiota by pyrosequencing reveals dissimilarity to the genital microbiota of healthy humans.
Article in AIDS research and human retroviruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.PloS one · 2015Trial
- Microbial Contributions to Primate Reproduction.Evolutionary anthropology · 2026Review
- Methods to characterize the vaginal microbiome in a rhesus macaque model of simian human immunodeficiency virus (SHIV) transmission uncover epithelium-associated enrichment ofCurrent research in microbial sciences · 2026Article
- Non-human primate models for understanding the impact of the microbiome on pregnancy and the female reproductive tract†.Biology of reproduction · 2023Review
- Role of the human vaginal microbiota in the regulation of inflammation and sexually transmitted infection acquisition: Contribution of the non-human primate model to a better understanding?Frontiers in reproductive health · 2022Review
- The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to BecomeMicrobiology spectrum · 2021Article
- Microbiome Studies in Non-human Primates.Current HIV/AIDS reports · 2021Review
- Article
- Longitudinal Profiling of the Macaque Vaginal Microbiome Reveals Similarities to Diverse Human Vaginal Communities.mSystems · 2021Article
- A common vaginal microbiota composition among breeds of Bos taurus indicus (Gyr and Nellore).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques.Frontiers in cellular and infection microbiology · 2019Article
- Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.Journal of medical primatology · 2017Article
- Ovarian cycling and reproductive state shape the vaginal microbiota in wild baboons.Microbiome · 2017Article
- Lactobacilli Dominance and Vaginal pH: Why Is the Human Vaginal Microbiome Unique?Frontiers in microbiology · 2016Article
- Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques.Sexually transmitted diseases · 2015Article
- Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques (Macaca leonina).Dong wu xue yan jiu = Zoological research · 2015Article
- Chlamydia caviae infection alters abundance but not composition of the guinea pig vaginal microbiota.Pathogens and disease · 2015Article
- Influence of age, reproductive cycling status, and menstruation on the vaginal microbiome in baboons (Papio anubis).American journal of primatology · 2015Article
- Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US.PloS one · 2014Article
- Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.Journal of virology · 2012Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Vaginal bacterial communities play an important role in human health and have been shown to influence HIV infection. Pigtailed macaques (Macaca nemestrina) are used as an animal model of HIV vaginal infection of women. Since the bacterial microbiota could influence retrovirus infection of pigtailed macaques, the genital microbiota in 10 cycling macaques was determined by pyrosequencing. The microbiota of all macaques was polymicrobial with a median of 13 distinct genera. Strikingly, the genera Sneathia and Fusobacterium, both in the phylum Fusobacteria, accounted for 18.9% and 13.3% of sequences while the next most frequent were Prevotella (5.6%), Porphyromonas (4.1%), Atopobium (3.6%), and Parvimonas (2.6%). Sequences corresponding to Lactobacillus comprised only 2.2% of sequences on average and were essentially all L. amylovorus. Longitudinal sampling of the 10 macaques over an 8-week period, which spanned at least one full ovulatory cycle, showed a generally stable presence of the major types of bacteria with some exceptions. These studies show that the microbiota of the pigtailed macaques is substantially dissimilar to that found in most healthy humans, where the genital microbiota is usually dominated by Lactobacillus sp. The polymicrobial makeup of the macaque bacterial populations, the paucity of lactobacilli, and the specific types of bacteria present suggest that the pigtailed macaque microbiota could influence vaginal retrovirus infection.
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