Evidence map›Paper›PMID 22263713›Full record

ArticleSubstance abuse2012

A multisite pilot study of extended-release injectable naltrexone treatment for previously opioid-dependent parolees and probationers.

Donna M Coviello, James W Cornish, Kevin G Lynch, Tamara Y Boney, Cynthia A Clark, Joshua D Lee, Peter D Friedmann, Edward V Nunes, Timothy W Kinlock, Michael S Gordon and 3 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Substance abuse, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pharmacotherapy for opioid addiction in community corrections.International review of psychiatry (Abingdon, England) · 2018
    Pooled it
  2. Pooled it
  3. Pharmacological interventions for drug-using offenders.The Cochrane database of systematic reviews · 2015
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Does mandating offenders to treatment improve completion rates?Journal of substance abuse treatment · 2013
    Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. The neurobiology of addiction.Annals of the New York Academy of Sciences · 2019
    Article
  17. Article
  18. Article
  19. Italian psychiatry.International review of psychiatry (Abingdon, England) · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Donna M CovielloUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA. coviello d@mail.trc.upenn.edu
James W Cornish
Kevin G Lynch
Tamara Y Boney
Cynthia A Clark
Joshua D Lee
Peter D Friedmann
Edward V Nunes
Timothy W Kinlock
Michael S Gordon
Robert P Schwartz
Elie S Nuwayser
Charles P O'Brien
University of Pennsylvania · USFriends Research Institute · USColumbia University · USNew York University · USRhode Island Hospital · USUniversity of Baltimore · USVeterans Health Administration · US

Funding

NALTREXONE TREATMENT OF OPIOID DEPENDENT PAROLEESR01DA012268 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CORNISH, JAMES W. · 2000 to 2006
$2.4M
NIDA NIH HHS R01 DA012268NIDA NIH HHS R01-DA-012268-05
6 · The paper itself

Abstract

A feasibility study was conducted to pilot test the ability of 5 sites to recruit, treat, and retain opioid-dependent offenders in a trial of extended-release injectable naltrexone (XR-NTX). The participants, 61 previously opioid-dependent individuals under legal supervision in the community, received up to 6 monthly injections of Depotrex brand naltrexone and completed a 6-month follow-up interview. Six-month outcomes showed that those who completed treatment had significantly fewer opioid-positive urines and were less likely to have been incarcerated than those who had not completed treatment. The findings indicate that XR-NTX holds promise as a feasible, effective treatment option for opioid-dependent offenders.

Indexed as

Opiate Substitution TreatmentPrisonersAdultDelayed-Action PreparationsFeasibility StudiesFemaleFollow-Up StudiesHumansInjectionsInjections, SubcutaneousMaleMiddle AgedNaltrexoneNarcotic AntagonistsOpioid-Related DisordersPilot ProjectsDelayed-Action PreparationsNaltrexoneNarcotic Antagonists

Identifiers

PMID22263713
PMCPMC3365863
OpenAlexW2024278700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.