ArticleJournal of thoracic disease2010
The role of gene expression profiling in early-stage non-small cell lung cancer.
Article in Journal of thoracic disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic implications of tumor-infiltrating lymphocytes in non-small cell lung cancer: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Metformin Directly Binds to MMP-9 to Improve Plaque Stability.Journal of cardiovascular development and disease · 2023Article
- The prognostic role of PD-1, PD-L1, ALK, and ROS1 proteins expression in non-small cell lung carcinoma patients from Egypt.Journal of the Egyptian National Cancer Institute · 2022Article
- New Perspectives in Different Gene Expression Profiles for Early and Locally Advanced Non-Small Cell Lung Cancer Stem Cells.Frontiers in oncology · 2021Article
- Single-Sample Node Entropy for Molecular Transition in Pre-deterioration Stage of Cancer.Frontiers in bioengineering and biotechnology · 2020Article
- Transforming growth factor β-induced epithelial-to-mesenchymal signature predicts metastasis-free survival in non-small cell lung cancer.Oncotarget · 2019Article
- Overlapping group screening for detection of gene-gene interactions: application to gene expression profiles with survival trait.BMC bioinformatics · 2018Article
- Test on existence of histology subtype-specific prognostic signatures among early stage lung adenocarcinoma and squamous cell carcinoma patients using a Cox-model based filter.Biology direct · 2015Article
- VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer.Journal of thoracic disease · 2013Article
- Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells.Molecular biology reports · 2013Article
- Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma.Molecular biology reports · 2013Article
- Expression and significance of RKIP and E-cadherin in lung squamous cell carcinoma.Pathology oncology research : POR · 2013Article
- The relationship between Bmi-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Expression of GPC3 protein and its significance in lung squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.Molecular biology reports · 2012Article
- Gene expression assays as prognostic and predictive markers in early stage non-small cell lung cancer.Journal of thoracic disease · 2012Article
- PEBP4 gene expression and its significance in invasion and metastasis of non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- The expression of PEBP4 protein in lung squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- The expression of p33(ING1), p53, and autophagy-related gene Beclin1 in patients with non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For patients with identical clinical-pathological characteristics or the same stage of lung cancer, great uncertainties remain regarding how some patients will be cured while other patients will have cancer recurrence, metastasis, or death after surgical resection. Identification of patients at high risk of recurrence, those who are unlikely to respond to specific chemotherapeutic agents, is the rationale for measuring specific biochemical markers. Thus, main investigational studies nowadays are focused in identifying molecular markers of recurrence, beyond pathologic stage, after surgical treatment and factors that can predict a benefit from adjuvant chemotherapy in poor prognosis subgroups, to individualize treatments. Advances in genomics and proteomics have generated many candidate markers with potential clinical value. Gene expression profiling (GEP) by microarray or real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) can be useful in the classification or prognosis of various types of cancer, including lung cancer. A number of prognostic gene expression signatures have been reported to predict survival in non-small cell lung cancer (NSCLC). In this review, we focus on the role of GEP in early-stage NSCLC as predictive and prognostic biomarker and its potential use for a 'personalized' medicine in the years to come.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.