ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Short-term plasticity of unitary inhibitory-to-inhibitory synapses depends on the presynaptic interneuron subtype.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 108 citations in OpenAlex.
- Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties.Communications biology · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.The Journal of physiology · 2026Article
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Conditional learning increases inhibition of layer 4 excitatory neurons by somatostatin- and parvalbumin-expressing interneurons in the barrel cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Lateralized local circuit tuning in female mouse auditory cortex.Neuroscience research · 2025Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A comprehensive data-driven model of cat primary visual cortex.PLoS computational biology · 2024Article
- Conditioning and pseudoconditioning differently change intrinsic excitability of inhibitory interneurons in the neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Sleep and wake in a model of the thalamocortical system with Martinotti cells.The European journal of neuroscience · 2024Article
- Article
- Pharmacological Signature and Target Specificity of Inhibitory Circuits Formed by Martinotti Cells in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Bicuculline restores frequency-dependent hippocampal I/E ratio and circuit function in PGC-1ɑ null mice.Neuroscience research · 2022Article
- Local connectivity and synaptic dynamics in mouse and human neocortex.Science (New York, N.Y.) · 2022Article
- Neural Substrates and Models of Omission Responses and Predictive Processes.Frontiers in neural circuits · 2022Review
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.Molecular psychiatry · 2021Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Excitatory-to-inhibitory cortical synapses exhibit either short-term facilitation or depression, depending on the subtype identity of the postsynaptic interneuron, while the short-term plasticity (STP) of inhibitory-to-excitatory synapses depends on the presynaptic interneuron. However, the rules governing STP of inhibitory-to-inhibitory synapses have not yet been determined. We recorded 109 unitary connections made by the two major inhibitory interneuron subtypes in layer 4 of mouse somatosensory cortex, fast-spiking (FS) and somatostatin-containing (SOM) interneurons, on each other and on excitatory, regular-spiking (RS) neurons. In all pairs, we measured dynamic changes in the postsynaptic response to a 20 Hz train of presynaptic action potentials. In half of our dataset, we also measured kinetic properties of the unitary IPSC: latency, rise time, and decay time constant. We found a pronounced dependency of STP on the presynaptic, but not the postsynaptic, identity: FS interneurons made strongly depressing connections on FS, SOM, and RS targets, while in synapses made by SOM interneurons on FS and RS targets, weak early depression was followed by weak late facilitation. IPSC latency and rise time were also strongly dependent on the presynaptic interneuron subtype, being 1.5-2× slower in output synapses of SOM compared with FS interneurons. In contrast, the IPSC decay time constant depended only on the postsynaptic class, with 1.5× slower decay on excitatory compared with inhibitory targets. The properties of the inhibitory outputs of FS and SOM interneurons reciprocate the properties of their excitatory inputs and imply a dynamic spatiotemporal division of labor between these two major inhibitory subsystems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.