ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Identification and characterization of adverse effects in 21st century toxicology.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps.Journal of applied toxicology : JAT · 2026Review
- AquaticTox: A Web-Based Tool for Aquatic Toxicity Evaluation Based on Ensemble Learning to Facilitate the Screening of Green Chemicals.Environment & health (Washington, D.C.) · 2024Article
- Editorial: Five grand challenges in toxicology.Frontiers in toxicology · 2024Article
- Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin.Archives of toxicology · 2023Article
- Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways.Environmental science & technology · 2023Article
- Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures.Frontiers in public health · 2021Article
- Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Improved Algal Toxicity Test System for RobustMetabolites · 2019Article
- Machine Learning to Predict, Detect, and Intervene Older Adults Vulnerable for Adverse Drug Events in the Emergency Department.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2018Review
- Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles.EFSA journal. European Food Safety Authority · 2018Article
- Guidance on the assessment of the biological relevance of data in scientific assessments.EFSA journal. European Food Safety Authority · 2017Article
- Scientific Opinion addressing the state of the science on risk assessment of plant protection products for in-soil organisms.EFSA journal. European Food Safety Authority · 2017Article
- Is It Adverse, Nonadverse, Adaptive, or Artifact?Toxicologic pathology · 2017Article
- Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.Environmental health perspectives · 2016Article
- Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.Archives of toxicology · 2015Article
- FutureTox II: in vitro data and in silico models for predictive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Allergic sensitization: screening methods.Clinical and translational allergy · 2014Article
- Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays.Current topics in medicinal chemistry · 2014Review
- A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes.Frontiers in genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The practice of toxicology is changing rapidly, as demonstrated by the response to the 2007 NRC report on "Toxicity Testing in the 21(st) Century." New assays are being developed to replace animal testing; yet the use of data from these assays in decision making is not clear. A Health and Environmental Sciences Institute committee held a May 2011 workshop to discuss approaches to identifying adverse effects in the context of the NRC report. Scientists from industry, government, academia, and NGOs discussed two case studies and explored how information from new, high data content assays developed for screening can be used to differentiate adverse effects from adaptive responses. The terms "adverse effect" and "adaptive response" were defined, as well as two new terms, the relevant pathways of toxicological concern (RPTCs) and relevant responses for regulation (RRRs). RPTCs are biochemical pathways associated with adverse events and need to be elucidated before they are used in regulatory decision making. RRRs are endpoints that are the basis for risk assessment and may or may not be at the level of pathways. Workshop participants discussed the criteria for determining whether, at the RPTC level, an effect is potentially adverse or potentially indicative of adaptability, and how the use of prototypical, data-rich compounds could lead to a greater understanding of RPTCs and their use as RRRs. Also discussed was the use of RPTCs in a weight-of-evidence approach to risk assessment. Inclusion of data at this level could decrease uncertainty in risk assessments but will require the use of detailed dosimetry and consideration of exposure context and the time and dose continuum to yield scientifically based decisions. The results of this project point to the need for an extensive effort to characterize RPTCs and their use in risk assessment to make the vision of the 2007 NRC report a reality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.