Evidence map›Paper›PMID 22262485›Full record

ArticleMolecular and cellular biochemistry2012

Excessive dietary calcium in the disruption of structural and functional status of adult male reproductive system in rat with possible mechanism.

Amar K Chandra, Pallav Sengupta, Haimanti Goswami, Mahitosh Sarkar

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The association between iron, calcium, and oxidative stress in seminal plasma and sperm quality.Environmental science and pollution research international · 2019
    Article
  5. Metals and male reproduction: The possible mechanisms.Advanced biomedical research · 2014
    Article
  6. Is Mind-Body Relaxation By Yoga is Effective to Combat with Lifestyle Stress?Annals of medical and health sciences research · 2013
    Article
  7. Article
  8. Potential health impacts of hard water.International journal of preventive medicine · 2013
    Review
  9. Male reproductive health and yoga.International journal of yoga · 2013
    Article
  10. The Laboratory Rat: Relating Its Age With Human's.International journal of preventive medicine · 2013
    Article
  11. Article
  12. Thyroid function in male infertility.Frontiers in endocrinology · 2013
    Article
  13. Article
  14. Health Impacts of Yoga and Pranayama: A State-of-the-Art Review.International journal of preventive medicine · 2012
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amar K ChandraEndocrinology & Reproductive Physiology Laboratory, Department of Physiology, University College of Science & Technology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, 700 009 West Bengal, India. amark_chandra@yahoo.co.in
Pallav Sengupta
Haimanti Goswami
Mahitosh Sarkar
University of Calcutta · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium is essential for functioning of different systems including male reproduction. However, it has also been reported as chemo-castrative agent. The study has been undertaken to elucidate the effect of excessive dietary calcium on male reproductive system in animals with possible action. Adult male healthy rats fed CaCl(2) at different doses (0.5, 1.0 and 1.5 g%) in diet for 13 and 26 days to investigate reproductive parameters as well as the markers of oxidative stress. Significant alteration was found (P < 0.05) in testicular and accessory sex organs weight, epididymal sperm count, testicular steroidogenic enzyme (Δ(5) 3β-HSD and 17β-HSD) activities, serum testosterone, LH, FSH, LPO, activities of antioxidant enzymes, testicular histoarchitecture along with adrenal Δ(5) 3β-HSD activity with corticosterone level in dose- and time-dependent manner. Overall observations suggest that excessive dietary calcium enhances the generation of free-radicals resulting in structural and functional disruption of male reproduction.

Indexed as

AnimalsAntioxidantsCalcium, DietaryCorticosteroneDose-Response Relationship, DrugFree RadicalsMaleOrgan SizeOxidative StressRatsReproductionSperm CountTestisTestosteroneAntioxidantsCalcium, DietaryCorticosteroneFree RadicalsTestosterone

Identifiers

PMID22262485
OpenAlexW2068950120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.