ArticleModern rheumatology2012
Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis.
Article in Modern rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Ultrasonographic features of IgG4-related kidney disease: diagnostic value and correlation with clinical-pathological findings.Frontiers in medicine · 2025Article
- Improved Renal Function in Initial Treatment Improves Patient Survival, Renal Outcomes, and Glucocorticoid-Related Complications in IgG4-Related Kidney Disease in Japan.Kidney international reports · 2024Article
- Persistent enlargement of the pancreatic gland after glucocorticoid therapy increases the risk of relapse in IgG4-related autoimmune pancreatitis.Clinical rheumatology · 2022Article
- An enigmatic case of IgG4-related nephropathy and an updated review of the literature.Clinical and experimental medicine · 2021Review
- Renal Involvement in IgG4-Related Disease: From Sunlight to Twilight.Frontiers in medicine · 2021Article
- Long-term effects of intensive B cell depletion therapy in severe cases of IgG4-related disease with renal involvement.Immunologic research · 2020Article
- Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan.Arthritis research & therapy · 2020Article
- IgG4-related lung disease progressing to respiratory failure.Respirology case reports · 2020Article
- Acute Tubulointerstitial Nephritis as a Sole Manifestation of Immunoglobulin G4-Related Disease.Journal of medical cases · 2019Article
- Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Retroperitoneal Fibrosis Diagnosed as IgG4-related Disease after 35 Years.Internal medicine (Tokyo, Japan) · 2019Article
- A case of IgG4-related kidney disease with predominantly unilateral renal atrophy.CEN case reports · 2019Article
- FOXP3Pediatric nephrology (Berlin, Germany) · 2018Article
- High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach.Pathology research international · 2017Article
- Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study.Arthritis research & therapy · 2016Article
- IgG4-related inflammatory pseudotumor of the kidney mimicking renal cell carcinoma: A case report.Oncology letters · 2016Article
- Recovery of renal function after glucocorticoid therapy for IgG4-related kidney disease with renal dysfunction.Clinical and experimental nephrology · 2016Article
- Recognizing IgG4-related tubulointerstitial nephritis.Canadian journal of kidney health and disease · 2016Review
- IgG4-related disease and the kidney.Nature reviews. Nephrology · 2015Review
- Tubulointerstitial fibrosis in patients with IgG4-related kidney disease: pathological findings on repeat renal biopsy.Rheumatology international · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN).
methodsWe studied six IgG4-related TIN patients receiving renal biopsies before and after corticosteroid therapy. Their clinical data and histological findings were evaluated before and after therapy.
resultsElevated serum creatinine levels rapidly improved after corticosteroid therapy except for two patients, in whom it persisted. Abnormal radiological findings improved in all patients, although focal cortical atrophy persisted in three. Histologically, TIN-like dense lymphoplasmacytic infiltration, interstitial fibrosis, IgG4-positive plasma cell, CD4+CD25+ T cell, and Foxp3+ cell infiltration were characteristic before therapy. After therapy, the area with cell infiltration decreased and regional fibrosis became evident in the renal interstitium. The number of IgG4-positive plasma cells and Foxp3+ cells significantly diminished even in the early stage of therapy, whereas low to moderate numbers of CD4+ and CD8+ T cells still infiltrated where inflammation persisted in the later stage.
conclusionsOur study shows that persistent renal insufficiency associated with macroscopic atrophy and microscopic fibrosis is not so rare in IgG4-related TIN. Pathologically, the behavior of regulatory T cells during the clinical course is quite similar to that of IgG4-positive plasma cells, and the behavior pattern of those cells is distinctive.
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