ArticleMolecular biology of the cell2012
The first luminal loop confers insulin responsiveness to glucose transporter 4.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Akt may associate with insulin-responsive vesicles via interaction with sortilin.FEBS letters · 2024Article
- Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes.International journal of molecular sciences · 2023Article
- Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes.International journal of molecular sciences · 2021Article
- Detection of Detergent-sensitive Interactions Between Membrane Proteins.Journal of visualized experiments : JoVE · 2018Article
- Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes.Molecular biology of the cell · 2017Article
- Internalization of the Active Subunit of theFrontiers in cellular and infection microbiology · 2017Article
- Alternative routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4.Journal of cell science · 2015Article
- Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin.Molecular biology of the cell · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Glucose transporter isoform 4 (GLUT4), is the sole glucose transporter responsible for the effect of insulin on postprandial blood glucose clearance. However, the nature of the insulin sensitivity of GLUT4 remains unknown. In this study, we replaced the first luminal loop of cellugyrin, a 4-transmembrane protein that does not respond to insulin, with that of GLUT4. The chimera protein is targeted to the intracellular insulin-responsive vesicles and is translocated to the plasma membrane upon insulin stimulation. The faithful targeting of the chimera depends on the expression of the sorting receptor sortilin, which interacts with the unique amino acid residues in the first luminal loop of GLUT4. Thus the first luminal loop may confer insulin responsiveness to the GLUT4 molecule.
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Registered trials
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