ArticleMolecular biology of the cell2012
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A non-transcriptional mitotic function of POU/Oct factors ensures spindle assembly and chromosome segregation.Journal of cell science · 2026Article
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- Waves in Embryonic Development.Annual review of biophysics · 2022Review
- Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021Article
- Doxorubicin Improves Cancer Cell Targeting by Filamentous Phage Gene Delivery Vectors.International journal of molecular sciences · 2020Article
- The role of dNTP metabolites in control of the embryonic cell cycle.Cell cycle (Georgetown, Tex.) · 2019Review
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
- Review
- A Topology-Centric View on Mitotic Chromosome Architecture.International journal of molecular sciences · 2017Review
- Dynamic Control of dNTP Synthesis in Early Embryos.Developmental cell · 2017Article
- Contribution of cell proliferation to axial elongation in the red flour beetle Tribolium castaneum.PloS one · 2017Article
- Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.Developmental cell · 2016Article
- Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.Trends in genetics : TIG · 2016Review
- The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.Nature cell biology · 2016Article
- Aurora B-mediated localized delays in nuclear envelope formation facilitate inclusion of late-segregating chromosome fragments.Molecular biology of the cell · 2015Article
- Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition.Cell · 2015Article
- Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila.Genetics · 2014Article
- Article
- WEE1 tyrosine kinase, a novel epigenetic modifier.Trends in genetics : TIG · 2013Review
- Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1.Clinics (Sao Paulo, Brazil) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Defects in DNA replication and chromosome condensation are common phenotypes in cancer cells. A link between replication and condensation has been established, but little is known about the role of checkpoints in monitoring chromosome condensation. We investigate this function by live analysis, using the rapid division cycles in the early Drosophila embryo. We find that S-phase and topoisomerase inhibitors delay both the initiation and the rate of chromosome condensation. These cell cycle delays are mediated by the cell cycle kinases chk1 and wee1. Inhibitors that cause severe defects in chromosome condensation and congression on the metaphase plate result in delayed anaphase entry. These delays are mediated by wee1 and are not the result of spindle assembly checkpoint activation. In addition, we provide the first detailed live analysis of the direct effect of widely used anticancer agents (aclarubicin, ICRF-193, VM26, doxorubicin, camptothecin, aphidicolin, hydroxyurea, cisplatin, mechlorethamine and x-rays) on key nuclear and cytoplasmic cell cycle events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.