ArticleInternational journal of cancer2012
Toenail trace element status and risk of Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Chromium as a Risk Factor for Breast Cancer: A Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Association between selenium levels and oesophageal adenocarcinoma risk: evidence from a meta-analysis.Bioscience reports · 2016Pooled it
- A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers.PloS one · 2014Trial
- Portable X-ray fluorescence of zinc and selenium with nail clippings-Mother and Infant Nutrition Investigation (MINI).PloS one · 2024Article
- Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study.Archives of Iranian medicine · 2023Article
- Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study.Journal of exposure science & environmental epidemiology · 2023Article
- Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow's Health cohort.Frontiers in public health · 2023Article
- Toenails as biomarker of exposure to essential trace metals: A review.Environmental research · 2019Review
- Methylmercury exposure, genetic variation in metabolic enzymes, and the risk of glioma.Scientific reports · 2019Article
- Do Post-breast Cancer Diagnosis Toenail Trace Element Concentrations Reflect Prediagnostic Concentrations?Epidemiology (Cambridge, Mass.) · 2019Article
- Urine and toenail cadmium levels in pregnant women: A reliability study.Environment international · 2018Article
- Toenail Chromium Concentration and Metabolic Syndrome among Korean Adults.International journal of environmental research and public health · 2018Article
- Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study.PloS one · 2018Article
- Toenail mineral concentration and risk of esophageal squamous cell carcinoma, results from the Golestan Cohort Study.Cancer medicine · 2017Article
- Trace element contents in toenails are related to regular physical activity in older adults.PloS one · 2017Article
- Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a U.S. Cohort.Environmental science & technology · 2016Article
- Dietary Risk Reduction Factors for the Barrett's Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature.Current nutrition reports · 2015Article
- Systematic review of zinc biomarkers and esophageal cancer risk.Middle East journal of digestive diseases · 2014Review
- Diet and esophageal disease.Annals of the New York Academy of Sciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Trace elements have been cited as both inhibitory and causative agents of cancer but importantly exposure to them is potentially modifiable. Our study aimed to examine toenail trace element status and risk of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). Toenail clippings from each hallux were obtained from 638 participants of the FINBAR (Factors Influencing the Barrett's Adenocarcinoma Relationship) study comprising 221 healthy controls, 98 reflux oesophagitis, 182 BO and 137 OAC cases. The concentrations of eight toenail trace elements were determined using instrumental neutron activation analysis. Using multivariable adjusted logistic regression analysis, odds ratios (OR) and 95% confidence intervals (CIs) were calculated within tertiles of trace element concentrations. A twofold increased risk of BO was observed, but not OAC, among individuals in the highest tertile of toenail zinc status OR 2.21 (95% CI, 1.11-4.40). A higher toenail selenium status was not associated with risk of OAC OR 0.94 (95% CI, 0.44-2.04) or BO OR 0.89 (95% CI, 0.37-2.12). A borderline significant increased risk of BO was detected with a higher toenail cobalt concentration, OR 1.97 (95% CI, 1.01-3.85). No association was found between toenail levels of chromium, cerium, mercury and OAC or BO risk. This is the first case-control study to investigate a variety of trace elements in relation to OAC and BO risk. Despite antioxidant and proapoptotic properties, no associations were found with selenium. Higher concentrations of toenail zinc and cobalt were associated with an increased BO risk, but not OAC. These findings need confirmation in prospective analysis.
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Registered trials
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