ArticleThe Analyst2012
Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices.
Article in The Analyst, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 32 citations in OpenAlex.
- A low-cost color sensor device for rapid detection of high-grade serous ovarian carcinoma (HGSOC).Oncoscience · 2026Article
- The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes.Sensors (Basel, Switzerland) · 2020Review
- Label-Free Direct Electrical Detection of a Histidine-Rich Protein with Sub-Femtomolar Sensitivity using an Organic Field-Effect Transistor.ChemistryOpen · 2017Article
- Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor.Micromachines · 2016Article
- Construction of an off-on fluorescence system based on carbon dots for trace pyrophosphate sensing.Journal of fluorescence · 2015Article
- Electrical detection of nucleic acid amplification using an on-chip quasi-reference electrode and a PVC REFET.Analytical chemistry · 2014Article
- A high-throughput screening method to reengineer DNA polymerases for random mutagenesis.Molecular biotechnology · 2014Article
- Surface immobilizable chelator for label-free electrical detection of pyrophosphate.Chemical communications (Cambridge, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
We introduce a label-free approach for sensing polymerase reactions on deoxyribonucleic acid (DNA) using a chelator-modified silicon-on-insulator field-effect transistor (SOI-FET) that exhibits selective and reversible electrical response to pyrophosphate anions. The chemical modification of the sensor surface was designed to include rolling-circle amplification (RCA) DNA colonies for locally enhanced pyrophosphate (PPi) signal generation and sensors with immobilized chelators for capture and surface-sensitive detection of diffusible reaction by-products. While detecting arrays of enzymatic base incorporation reactions is typically accomplished using optical fluorescence or chemiluminescence techniques, our results suggest that it is possible to develop scalable and portable PPi-specific sensors and platforms for broad biomedical applications such as DNA sequencing and microbe detection using surface-sensitive electrical readout techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.