ArticleJournal of cellular physiology2012
Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP.
Article in Journal of cellular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Using High-Throughput Screening to Identify Crosslinking Peptides That Control Cell-Mediated Matrix Degradation.Advanced healthcare materials · 2025Article
- Fibrin-based Bioinks: New Tricks from an Old Dog.International journal of bioprinting · 2020Review
- Deciphering the relative roles of matrix metalloproteinase- and plasmin-mediated matrix degradation during capillary morphogenesis using engineered hydrogels.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Cellular Based Strategies for Microvascular Engineering.Stem cell reviews and reports · 2019Review
- The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure.Stem cell research & therapy · 2018Review
- Effects of CoClExperimental and therapeutic medicine · 2018Article
- Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures.Scientific reports · 2018Article
- Microvascular Networks From Endothelial Cells and Mesenchymal Stromal Cells From Adipose Tissue and Bone Marrow: A Comparison.Frontiers in bioengineering and biotechnology · 2018Article
- Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14.Scientific reports · 2016Article
- Adipose-derived stem cells increase angiogenesis through matrix metalloproteinase-dependent collagen remodeling.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Soluble factors from biofilms of wound pathogens modulate human bone marrow-derived stromal cell differentiation, migration, angiogenesis, and cytokine secretion.BMC microbiology · 2015Article
- CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells.BioResearch open access · 2015Article
- Vascularization mediated by mesenchymal stem cells from bone marrow and adipose tissue: a comparison.Cell regeneration (London, England) · 2015Article
- Protease-sensitive PEG hydrogels regulate vascularization in vitro and in vivo.Macromolecular bioscience · 2014Article
- Laminin promotes vascular network formation in 3D in vitro collagen scaffolds by regulating VEGF uptake.Experimental cell research · 2014Article
- Sculpting the blank slate: how fibrin's support of vascularization can inspire biomaterial design.Acta biomaterialia · 2014Review
- A safe and efficient method to retrieve mesenchymal stem cells from three-dimensional fibrin gels.Tissue engineering. Part C, Methods · 2014Article
- Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor.Experimental cell research · 2013Article
- Cell-based approaches to the engineering of vascularized bone tissue.Cytotherapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bone marrow-derived stromal/stem cells (BMSCs) have recently been characterized as mediators of tissue regeneration after injury. In addition to preventing fibrosis at the wound site, BMSCs elicit an angiogenic response within the fibrin matrix. The mechanistic interactions between BMSCs and invading endothelial cells (ECs) during this process are not fully understood. Using a three-dimensional, fibrin-based angiogenesis model, we sought to investigate the proteolytic mechanisms by which BMSCs promote vessel morphogenesis. We find that BMSC-mediated vessel formation depends on the proteolytic ability of membrane type 1-matrix metalloproteinase (MT1-MMP). Knockdown of the protease results in a small network of vessels with enlarged lumens. Contrastingly, vessel morphogenesis is unaffected by the knockdown of MMP-2 and MMP-9. Furthermore, we find that BMSC-mediated vessel morphogenesis in vivo follows mechanisms similar to what we observe in vitro. Subcutaneous, cellular fibrin implants in C.B-17/SCID mice form aberrant vasculature when MMPs are inhibited with a broad-spectrum chemical inhibitor, and a very minimal amount of vessels when MT1-MMP proteolytic activity is interrupted in ECs. Other studies have debated the necessity of MT1-MMP in the context of vessel invasion in fibrin, but this study clearly demonstrates its requirement in BMSC-mediated angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.