ReviewCurrent opinion in clinical nutrition and metabolic care2012
Antioxidants and micronutrient supplementation in trauma patients.
Review in Current opinion in clinical nutrition and metabolic care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients.International journal of molecular sciences · 2017Trial
- Perioperative Immunonutrition for Elective Surgery: Review of Mechanisms, Summary of Evidence, and Future Directions.Nutrients · 2026Review
- Selenium as an Antioxidant: Roles and Clinical Applications in Critically Ill and Trauma Patients: A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Innate Immune System Response to Burn Damage-Focus on Cytokine Alteration.International journal of molecular sciences · 2022Review
- Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions.NPJ microgravity · 2021Review
- Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis.Annals of intensive care · 2019Review
- Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- Analysis of oxidative stress-related markers in critically ill polytrauma patients: An observational prospective single-center study.Bosnian journal of basic medical sciences · 2018Observational
- Antioxidant and Trace Element Supplementation Reduce the Inflammatory Response in Critically Ill Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2018Article
- Influence of antioxidant therapy on the clinical status of multiple trauma patients. A retrospective single center study.Romanian journal of anaesthesia and intensive care · 2015Article
- Benefits of antioxidant supplementation in multi-trauma patients.Romanian journal of anaesthesia and intensive care · 2015Article
- Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis study reviews important nutrients responsible for oxidant-antioxidant balance in trauma patients requiring admission to the ICU and rationale for repletion of antioxidants using pharmaconutrition. RECENT
findingsOxidative stress is an underlying cause of critical illness due to oxidant-antioxidant imbalance. Multiple nutrients important to oxidative balance have been studied, yet much variety exists among the dosing, timing, and route of administration. Conflict also exists regarding the benefits of particular single nutrients and the effects of combination therapy. Anticipated results of the Reducing Deaths due to Oxidative Stress trial hope to provide further insight to the use of antioxidants in critically ill patients. SUMMARY: The goal of this review, though not exhaustive, serves to highlight recent significant studies regarding antioxidant use in the ICU setting while calling for sufficiently powered randomized, controlled trials to elucidate appropriate guidelines for antioxidant administration in regards to ideal dosing, route of administration, timing of administration, duration of therapy, and the role of single versus combination supplementation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.