ReviewThe Lancet. Neurology2012
Genetic [corrected] insights into the causes and classification of [corrected] cerebral palsies.
Review in The Lancet. Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews.The Cochrane database of systematic reviews · 2018Pooled it
- Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews.The Cochrane database of systematic reviews · 2017Pooled it
- X-chromosomal genetic variants and haplotype analysis in male cerebral palsy patients: insights into genetic susceptibility and sex-specific risk.Journal of neurodevelopmental disorders · 2026Article
- Knee Joint Loading During Supported Standing in Children and Adolescents with Severe Cerebral Palsy: Effects of Verticalization and Joint Position.Children (Basel, Switzerland) · 2026Article
- A Phenotypic Paradigm for Cerebral Palsy Genetics.medRxiv : the preprint server for health sciences · 2026Article
- Zebrafish in neurodevelopmental disorders studies: Genetic models and pathological involvement of microglia.Developmental medicine and child neurology · 2025Review
- Insights into the genetic landscape of cerebral palsy.Clinical and translational medicine · 2025Article
- Genetic Alterations in Atypical Cerebral Palsy Identified Through Chromosomal Microarray and Exome Sequencing.International journal of molecular sciences · 2025Article
- Exome sequencing in a Chinese cohort of children with cerebral palsy identifies likely pathogenic variants.Nature medicine · 2024Article
- Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy.Nature medicine · 2024Article
- Neuromuscular impairments of cerebral palsy: contributions to gait abnormalities and implications for treatment.Frontiers in human neuroscience · 2024Article
- Redefining cerebral palsies as a diverse group of neurodevelopmental disorders with genetic aetiology.Nature reviews. Neurology · 2023Review
- Development of a Bedside Tool to Predict the Diagnosis of Cerebral Palsy in Term-Born Neonates.JAMA pediatrics · 2023Article
- Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in Southern China: A Case-Control Study.Developmental neuroscience · 2023Article
- Clinical and biochemical footprints of inherited metabolic disease. V. Cerebral palsy phenotypes.Molecular genetics and metabolism · 2022Review
- The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population.BMC medical genomics · 2022Article
- Correlation between fetal heart rate evolution patterns and magnetic resonance imaging findings in severe cerebral palsy: A longitudinal study.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Outcomes of importance to children and young adults with cerebral palsy, their parents and health professionals following lower limb orthopaedic surgery: A qualitative study to inform a Core Outcome Set.Health expectations : an international journal of public participation in health care and health policy · 2022Article
- Dysregulation of multiple signaling pathways: A possible cause of cerebral palsy.Experimental biology and medicine (Maywood, N.J.) · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cerebral palsy-the most common physical disability of childhood-is a clinical diagnosis encompassing a heterogeneous group of neurodevelopmental disorders that cause impairments of movement and posture that persist throughout life. Despite being commonly attributed to a range of environmental factors, particularly birth asphyxia, the specific cause of cerebral palsy remains unknown in most individuals. A growing body of evidence suggests that cerebral palsy is probably caused by multiple genetic factors, similar to other neurodevelopmental disorders such as autism and intellectual disability. Recent advances in next-generation sequencing technologies have made possible rapid and cost-effective sequencing of the entire human genome. Novel cerebral palsy genes will probably be identified as more researchers and clinicians use this approach to study individuals with undiagnosed neurological disorders. As our knowledge of the underlying pathophysiological mechanisms of cerebral palsy increases, so will the possibility of developing genomically guided therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.