ArticleArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2012
Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model.
Article in Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- A Systematic Review of Tissue Engineering Scaffold in Tendon Bone HealingFrontiers in bioengineering and biotechnology · 2021Pooled it
- Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial.The American journal of sports medicine · 2020Trial
- Postcommercialisation outcomes of bridge-enhanced anterior cruciate ligament restoration: The first 100 Bridge registry patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Indications, Techniques, and Outcomes of Bridge-Enhanced ACL Restoration (BEAR).Current reviews in musculoskeletal medicine · 2025Review
- Bridge-Enhanced Anterior Cruciate Ligament Restoration: 6-Year Results From the First-in-Human Cohort Study.Orthopaedic journal of sports medicine · 2024Article
- Quantitative MRI Biomarkers to Predict Risk of Reinjury Within 2 Years After Bridge-Enhanced ACL Restoration.The American journal of sports medicine · 2023Article
- Advanced Gene Therapy Strategies for the Repair of ACL Injuries.International journal of molecular sciences · 2022Review
- Bridge-Enhanced Anterior Cruciate Ligament Repair for Mid-Substance Tear With Concomitant Lateral Meniscus Radial Repair.Arthroscopy techniques · 2022Article
- Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery.The American journal of sports medicine · 2022Article
- Quantitative high-resolution 7T MRI to assess longitudinal changes in articular cartilage after anterior cruciate ligament injury in a rabbit model of post-traumatic osteoarthritis.Osteoarthritis and cartilage open · 2022Article
- Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.Orthopaedic journal of sports medicine · 2022Article
- Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2021Article
- Effect of Skeletal Maturity on Fixation Techniques for Tibial Eminence Fractures.Orthopaedic journal of sports medicine · 2021Article
- Optimizing outcomes of ACL surgery-Is autograft reconstruction the only reasonable option?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Suture Tape Augmentation Has No Effect on Anterior Tibial Translation, Gap Formation, or Load to Failure of Anterior Cruciate Ligament Repair: A Biomechanical Pilot Study.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Positive effects of platelet-rich plasma (PRP) and aPharmaceutical biology · 2020Article
- Inter- and Intraobserver Reliability Between Orthopaedic Surgeons for Reparability of the Anterior Cruciate Ligament Using MRI.Orthopaedic journal of sports medicine · 2020Article
- Paediatric proximal ACL tears managed with direct ACL repair is safe, effective and has excellent short-term outcomes.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair.Orthopaedic journal of sports medicine · 2020Article
- Cruciate ligament healing and injury prevention in the age of regenerative medicine and technostress: homeostasis revisited.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe objective of this study was to compare the biomechanical outcomes of a new method of anterior cruciate ligament (ACL) treatment, bioenhanced ACL repair, with ACL reconstruction in a large animal model.
methodsTwenty-four skeletally immature pigs underwent unilateral ACL transection and were randomly allocated to receive bioenhanced ACL repair with a collagen-platelet composite, allograft (bone-patellar tendon-bone) reconstruction, or no further treatment (n = 8 for each group). The structural properties and anteroposterior laxity of the experimental and contralateral ACL-intact knees were measured 15 weeks postoperatively. All dependent variables were normalized to those of the contralateral knee and compared by use of generalized linear mixed models.
resultsAfter 15 weeks, bioenhanced ACL repair and ACL reconstruction produced superior biomechanical outcomes to ACL transection. However, there were no significant differences between bioenhanced ACL repair and ACL reconstruction for maximum load (P = .4745), maximum displacement (P = .4217), or linear stiffness (P = .6327). There were no significant differences between the 2 surgical techniques in anteroposterior laxity at 30° (P = .7947), 60° (P = .6270), or 90° (P = .9008).
conclusionsBioenhanced ACL repair produced biomechanical results that were not different from ACL reconstruction in a skeletally immature, large animal model, although the variability associated with both procedures was large. Both procedures produced significantly improved results over ACL transection, showing that both were effective treatments in this model. CLINICAL RELEVANCE: Bioenhanced ACL repair may one day provide an alternative treatment option for ACL injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.