ArticleBiophysical journal2011
Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- A CaJournal of mathematical biology · 2025Article
- Cross Talking Calcium, IPCell biochemistry and biophysics · 2024Article
- Modeling IPBiophysical journal · 2023Article
- A mathematical model of calcium signals around laser-induced epithelial wounds.Molecular biology of the cell · 2023Article
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Highly localized intracellular CaeLife · 2021Article
- Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells.Biophysical journal · 2021Article
- Disentangling astroglial physiology with a realistic cell model in silico.Nature communications · 2018Article
- Article
- A Bayesian approach to modelling heterogeneous calcium responses in cell populations.PLoS computational biology · 2017Article
- Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors.Biophysical journal · 2017Article
- Damped oscillations in a multiple delayed feedback NF-κB signaling module.European biophysics journal : EBJ · 2015Article
- Nonlinear and Stochastic Dynamics in the Heart.Physics reports · 2014Article
- An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging.Cell calcium · 2014Article
- Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.Science signaling · 2014Article
- Stochasticity in Ca2+ increase in spines enables robust and sensitive information coding.PloS one · 2014Article
- Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs.Biophysical journal · 2013Article
- The emergence of subcellular pacemaker sites for calcium waves and oscillations.The Journal of physiology · 2013Article
- A stochastic model of calcium puffs based on single-channel data.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The behavior of biological systems is determined by the properties of their component molecules, but the interactions are usually too complex to understand fully how molecular behavior generates cellular behavior. Ca(2+) signaling by inositol trisphosphate receptors (IP(3)R) offers an opportunity to understand this relationship because the cellular behavior is defined largely by Ca(2+)-mediated interactions between IP(3)R. Ca(2+) released by a cluster of IP(3)R (giving a local Ca(2+) puff) diffuses and ignites the behavior of neighboring clusters (to give repetitive global Ca(2+) spikes). We use total internal reflection fluorescence microscopy of two mammalian cell lines to define the temporal relationships between Ca(2+) puffs (interpuff intervals, IPI) and Ca(2+) spikes (interspike intervals) evoked by flash photolysis of caged IP(3). We find that IPI are much shorter than interspike intervals, that puff activity is stochastic with a recovery time that is much shorter than the refractory period of the cell, and that IPI are not periodic. We conclude that Ca(2+) spikes do not arise from oscillatory dynamics of IP(3)R clusters, but that repetitive Ca(2+) spiking with its longer timescales is an emergent property of the dynamics of the whole cluster array.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.