ArticleJournal of neuroscience methods2012
Calcium imaging of multiple neurons in freely behaving C. elegans.
Article in Journal of neuroscience methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Automated analysis of C. elegans behavior by LabGym: an open-source, AI-powered platform.G3 (Bethesda, Md.) · 2026Article
- A Real-Time Automated Deep Learning Workflow for Non-invasive High-Magnification Imaging ofbioRxiv : the preprint server for biology · 2026Article
- An epifluorescence microscope design for naturalistic behavior and cellular activity in freely moving Caenorhabditis elegans.Nature communications · 2026Article
- A modular multi-color fluorescence microscope for simultaneous tracking of cellular activity and behavior.Nature communications · 2026Article
- Automated analysis ofbioRxiv : the preprint server for biology · 2025Article
- Characterization of auditory sensation inBiophysics reports · 2024Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Advanced Neural Functional Imaging inMicromachines · 2024Review
- Article
- Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number.bioRxiv : the preprint server for biology · 2024Article
- Systematic generation of biophysically detailed models with generalization capability for non-spiking neurons.PloS one · 2022Article
- Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation inBio-protocol · 2021Article
- FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Pan-neuronal calcium imaging with cellular resolution in freely swimming zebrafish.Nature methods · 2017Article
- Pan-neuronal screening ineLife · 2016Article
- Flyception: imaging brain activity in freely walking fruit flies.Nature methods · 2016Article
- In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans.Scientific reports · 2016Article
- Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs.Cell cycle (Georgetown, Tex.) · 2015Article
- High-throughput imaging of neuronal activity in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The geometry of locomotive behavioral states in C. elegans.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Caenorhabditis elegans is a popular model organism to study how neural circuits and genes regulate behavior. To reliably correlate circuit function with behavior, it is important to record neuronal activity in freely behaving worms. As neural circuits are composed of multiple neurons that cooperate to process information, it is highly desirable to simultaneously record the activity of multiple neurons in the circuitry. However, such a system has not been available in C. elegans. Here, we report the CARIBN II (Calcium Ratiometric Imaging of Behaving Nematodes version II) system. This system provides smoother data collection and more importantly permits simultaneous imaging of calcium transients from multiple neurons in freely behaving worms. Using this system, we imaged the activity of AVA and RIM, two key neurons in the locomotion circuitry that regulate backward movement (reversal) in locomotion behavior. We found that AVA activity increases while RIM activity decreases during the same reversal events in spontaneous locomotion, consistent with the recent report that the AVA and RIM are involved in promoting the initiation of reversals. The CARIBN II system provides a valuable tool for dissecting the neural basis of behavior in C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.