Trial reportCirculation. Heart failure2012
Should women receive left ventricular assist device support?: findings from INTERMACS.
Trial report in Circulation. Heart failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Clinical effectiveness of therapy with continuous-flow left ventricular assist devices in nonischemic versus ischemic cardiomyopathy: a systematic review and meta-analysis.Canadian journal of surgery. Journal canadien de chirurgie · 2021Pooled it
- Addressing Disturbance in Bodily Experience After Ventricular Assist Device Implantation: A Multicenter Randomized Controlled Trial of Curricular Psychological Support.Artificial organs · 2025Trial
- Sex-based Differences in the Utility and Outcomes of Left Ventricular Assist Devices.Journal of the Saudi Heart Association · 2025Review
- The Influence of Arrhythmias and Metabolic Profile on Inpatient Mortality in Patients with Left Ventricular Assist Devices.Journal of clinical medicine · 2024Article
- Cardiomyopathies in Women.Methodist DeBakey cardiovascular journal · 2024Review
- Addressing Barriers for Women with Advanced Heart Failure.Current cardiology reports · 2023Review
- Sex-Based Differences in One-Year Outcomes After Mitral Valve Repair for Infective Endocarditis.Brazilian journal of cardiovascular surgery · 2023Article
- Sex Differences in Left Ventricular Assist Device-related Emergency Department Encounters in the United States.Journal of cardiac failure · 2022Article
- Sex disparities in the current era of pediatric heart transplantation in the United States.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Sex Differences in Recovery and Device Replacement After Left Ventricular Assist Device Implantation as Destination Therapy.Journal of the American Heart Association · 2022Article
- Representation of women in heart failure clinical trials: Barriers to enrollment and strategies to close the gap.American heart journal plus : cardiology research and practice · 2022Article
- Sex-based considerations for implementation of ventricular assist device therapy.Frontiers in cardiovascular medicine · 2022Review
- Improving Outcome Predictions for Patients Receiving Mechanical Circulatory Support by Optimizing Imputation of Missing Values.Circulation. Cardiovascular quality and outcomes · 2021Article
- Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2021Article
- Sex differences in outcomes following less-invasive left ventricular assist device implantation.Annals of cardiothoracic surgery · 2021Article
- Sex and Heart Failure Treatment Prescription and Adherence.Frontiers in cardiovascular medicine · 2021Review
- The total artificial heart in patients with congenital heart disease.Annals of cardiothoracic surgery · 2020Article
- Sex Influence on Heart Failure Prognosis.Frontiers in cardiovascular medicine · 2020Review
- Ambulatory Advanced Heart Failure in Women: A Report From the REVIVAL Registry.JACC. Heart failure · 2019Observational
- Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network.JACC. Heart failure · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSmall studies have reported women to have worse outcomes and more adverse events after implantation of mechanical circulatory support device compared with men. To further evaluate sex differences in outcome, we used the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). METHODS AND
resultsThere were 401 women (pulsatile devices=78) and 1535 men (pulsatile devices=402) from 89 institutions who were prospectively enrolled into the INTERMACS database for primary implantation of a left ventricular assist device (LVAD) between June 23, 2006, and March 31, 2010. Extensive preimplantation and outcome data were collected on all patients. With a mean follow-up of 7 months, 67 females (17%) died and 250 males (16%) died. There was no statistically significant sex difference in mortality for either pulsatile-flow (P=0.82) or continuous-flow (P=0.95) devices in adjusted and unadjusted models. There were also no statistically significant sex differences with time to first infection, bleeding, or device malfunction. However, female sex was associated with an increased hazard of first neurological event (adjusted hazard ratio, 1.44; 95% CI, 1.05-1.96; P=0.020).
conclusionsThere were no significant sex differences in mortality, time to first infection, bleeding, or device malfunction with either pulsatile- or continuous-flow LVADs. However, women had an increased risk of first neurological event. For urgent/emergent mechanical support, the benefit of LVAD support likely outweighs the risk, but it remains less clear for women undergoing elective LVAD implantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.