Evidence map›Paper›PMID 22260928›Full record

ArticleNanotechnology2012

Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging.

Hsiangkuo Yuan, Christopher G Khoury, Hanjun Hwang, Christy M Wilson, Gerald A Grant, Tuan Vo-Dinh

Abstract read
In one paragraph

Article in Nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed.

  1. Article
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  5. Article
  6. SERSµDrop: A Platform to Study Cell-Cell Communication via SERS Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Plasmonic-Hydrogel Hybrid Biomaterials Via In Situ Seeded Growth.Angewandte Chemie (International ed. in English) · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hsiangkuo YuanDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Christopher G Khoury
Hanjun Hwang
Christy M Wilson
Gerald A Grant
Tuan Vo-Dinh

Funding

Ultra-High-Throughput Screening (uHTS) Based on Surface*R01EB006201 · NIBIB · DUKE UNIVERSITY · PI VO-DINH, TUAN · 2006 to 2009
$1.9M
Nonobiosensors for Probing Chemical Exposure and Metabolism Pathways of IndividuaR01ES014774 · NIEHS · DUKE UNIVERSITY · PI VO-DINH, TUAN · 2007 to 2009
$1.0M
Modulation of the Blood-Tumor Barrier Through Targeted Suppression of Claudin 5K08NS075144 · NINDS · STANFORD UNIVERSITY · PI GRANT, GERALD ARTHUR · 2011 to 2015
$641k
NIBIB NIH HHS R01 EB006201NIEHS NIH HHS R01 ES014774NINDS NIH HHS K08 NS075144
6 · The paper itself

Abstract

Understanding the control of the optical and plasmonic properties of unique nanosystems--gold nanostars--both experimentally and theoretically permits superior design and fabrication for biomedical applications. Here, we present a new, surfactant-free synthesis method of biocompatible gold nanostars with adjustable geometry such that the plasmon band can be tuned into the near-infrared region 'tissue diagnostic window', which is most suitable for in vivo imaging. Theoretical modelling was performed for multiple-branched 3D nanostars and yielded absorption spectra in good agreement with experimental results. The plasmon band shift was attributed to variations in branch aspect ratio, and the plasmon band intensifies with increasing branch number, branch length, and overall star size. Nanostars showed an extremely strong two-photon photoluminescence (TPL) process. The TPL imaging of wheat-germ agglutinin (WGA) functionalized nanostars on BT549 breast cancer cells and of PEGylated nanostars circulating in the vasculature, examined through a dorsal window chamber in vivo in laboratory mouse studies, demonstrated that gold nanostars can serve as an efficient contrast agent for biological imaging applications.

Indexed as

Biocompatible MaterialsContrast MediaGoldNanostructuresAnimalsBreast NeoplasmsCell Line, TumorFemaleHumansLuminescenceLuminescent MeasurementsMiceMice, NudeNanotechnologyWheat Germ AgglutininsBiocompatible MaterialsContrast MediaGoldWheat Germ Agglutinins

Identifiers

PMID22260928
PMCPMC3400343

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.