ArticleNanotechnology2012
Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays.
Article in Nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Massart iron oxide nanoparticles in mechanobiology.Nanoscale advances · 2026Review
- Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays.Current protocols · 2022Article
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Soft Polymer-Based Technique for Cellular Force Sensing.Polymers · 2021Review
- Manipulation of Axonal Outgrowth via Exogenous Low Forces.International journal of molecular sciences · 2020Review
- (De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.Advanced healthcare materials · 2020Review
- Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Biomechanical Characterization at the Cell Scale: Present and Prospects.Frontiers in physiology · 2018Review
- Applications, Surface Modification and Functionalization of Nickel Nanorods.Materials (Basel, Switzerland) · 2017Review
- Understanding the extracellular forces that determine cell fate and maintenance.Development (Cambridge, England) · 2017Review
- Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.Scientific reports · 2016Article
- Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death.Advanced materials (Deerfield Beach, Fla.) · 2016Article
- Review of cellular mechanotransduction on micropost substrates.Medical & biological engineering & computing · 2016Review
- A microfabricated magnetic actuation device for mechanical conditioning of arrays of 3D microtissues.Lab on a chip · 2015Article
- Cytoskeletal Mechanics Regulating Amoeboid Cell Locomotion.Applied mechanics reviews · 2014Article
- Magnetic approaches to study collective three-dimensional cell mechanics in long-term cultures (invited).Journal of applied physics · 2014Article
- Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.Advanced materials (Deerfield Beach, Fla.) · 2013Article
- Microfabricated magnetic structures for future medicine: from sensors to cell actuators.Nanomedicine (London, England) · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this paper, the use of magnetic nanowires for the study of cellular response to force is demonstrated. High-aspect ratio Ni rods with diameter 300 nm and lengths up to 20 μm were bound to or internalized by pulmonary artery smooth muscle cells (SMCs) cultured on arrays of flexible micropost force sensors. Forces and torques were applied to the cells by driving the nanowires with AC magnetic fields in the frequency range 0.1-10 Hz, and the changes in cellular contractile forces were recorded with the microposts. These local stimulations yield global force reinforcement of the cells' traction forces, but this contractile reinforcement can be effectively suppressed upon addition of a calcium channel blocker, ruthenium red, suggesting the role of calcium channels in the mechanical response. The responsiveness of the SMCs to actuation depends on the frequency of the applied stimulation. These results show that the combination of magnetic nanoparticles and micropatterned, flexible substrates can provide new approaches to the study of cellular mechanotransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.