ReviewEnvironmental science & technology2012
Predictive environmental risk assessment of chemical mixtures: a conceptual framework.
Review in Environmental science & technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework.Risk analysis : an official publication of the Society for Risk Analysis · 2015Pooled it
- Assessing environmental exposures in children: toward a comprehensive exposome approach.Pediatric research · 2026Review
- Bioaccessibility and Health Risk Assessment of Heavy Metals in Commercially Available Rice from Central Iran: Implications for Food Safety.Biological trace element research · 2026Article
- A Comparative Multi-Bioassay Assessment of Tetracycline Mixture Toxicity in Water and Soil Using Harmonized Dose-Response Modeling.Journal of xenobiotics · 2026Article
- Life Stage-Dependent Toxicity and Interactions of Scrubber-Related Metal Mixtures in Marine Zooplankton.Toxics · 2026Article
- The Role of ES&T in Advancing Environmental Toxicology and Chemical Risk Assessment: Past, Present, and Future.Environmental science & technology · 2026Review
- Toxicity-informed control of global PMNational science review · 2026Article
- Zeolite-Based Composite Nanomaterials for Organic Micropollutant Removal: Structure-Property-Performance Relationships and Practical Challenges.Nanomaterials (Basel, Switzerland) · 2026Review
- Review
- Effects of environmentally relevant ibuprofen and valproic acid exposure on zebrafish behavior.Biomolecules & biomedicine · 2026Article
- An Integrated Review of Pesticides and Antibiotics in Agricultural Environments: Occurrence, Cross-Media Transport, and Plant Uptake.Foods (Basel, Switzerland) · 2026Review
- Article
- Risk assessment of a mixture of pharmaceuticals and personal care products (PPCPs) in thermal waters of Kütahya, Türkiye.Environmental geochemistry and health · 2026Article
- The Freshwater CiliateJournal of xenobiotics · 2026Article
- Advancing Aquatic Ecotoxicology Testing of Anticancer Drugs Through Mesocosms.Molecules (Basel, Switzerland) · 2025Review
- Four-Year Monitoring Survey of Pesticide Residues in Tomato Samples: Human Health and Environmental Risk Assessment.Journal of xenobiotics · 2025Article
- Exposure to marine contaminant mixtures with different toxicity drivers reduces microzooplankton diversity.FEMS microbiology ecology · 2025Article
- Mathematical models for predicting the toxicity of micropollutant mixtures in water.Arhiv za higijenu rada i toksikologiju · 2025Review
- Spatially and Seasonally Resolved Predictions Reveal Widespread Ecotoxicological Risk from Pharmaceutical Mixtures in German (Saxon) Rivers.Environmental science & technology · 2025Article
- Relevance of kinetic interactions and co-formulants for plant protection product liver toxicity in vitro.Archives of toxicology · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental risks of chemicals are still often assessed substance-by-substance, neglecting mixture effects. This may result in risk underestimations, as the typical exposure is toward multicomponent chemical "cocktails". We use the two well established mixture toxicity concepts (Concentration Addition (CA) and Independent Action (IA)) for providing a tiered outline for environmental hazard and risk assessments of mixtures, focusing on general industrial chemicals and assuming that the "base set" of data (EC50s for algae, crustaceans, fish) is available. As mixture toxicities higher than predicted by CA are rare findings, we suggest applying CA as a precautious first tier, irrespective of the modes/mechanisms of action of the mixture components. In particular, we prove that summing up PEC/PNEC ratios might serve as a justifiable CA-approximation, in order to estimate in a first tier assessment whether there is a potential risk for an exposed ecosystem if only base-set data are available. This makes optimum use of existing single substance assessments as more demanding mixture investigations are requested only if there are first indications of an environmental risk. Finally we suggest to call for mode-of-action driven analyses only if error estimations indicate the possibility for substantial differences between CA- and IA-based assessments.
Indexed as
Identifiers
22260322What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.