ArticleThe Korean journal of hematology2011
Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: Upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells.
Article in The Korean journal of hematology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Efficacy of intra-ovarian injection of autologous platelet-rich plasma in women with poor responders: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Platelet-Rich Plasma: An Endogenous Bioregulatory Modulator Coordinating Soft Tissue Remodeling.Aesthetic plastic surgery · 2026Review
- PRP-related biomaterials enhance bone and nerve repair.Materials today. Bio · 2026Review
- Assessment of Subepidermal Low-Echogenic Band via High-Frequency Ultrasound for Evaluating the Efficacy of Platelet-Rich Plasma Injection in Treating Facial Skin Photoaging: A Case Series.Journal of cosmetic dermatology · 2026Article
- Comparative analysis of liquid and gel platelet rich plasma from apheresis and buffy coat in wound healing.Scientific reports · 2025Article
- Platelet-rich plasma (PRP) in nerve repair.Regenerative therapy · 2024Review
- Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice.Drug delivery and translational research · 2022Article
- Platelet Derivatives and the Immunomodulation of Wound Healing.International journal of molecular sciences · 2022Review
- Evaluation of the efficacy of platelet rich fibrin (I-PRF) intra-articular injections in the management of internal derangements of temporomandibular joints - a controlled preliminary prospective clinical study.BMC musculoskeletal disorders · 2022Article
- Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts.International journal of molecular sciences · 2021Article
- Angiogenic Properties of Concentrated Growth Factors (CGFs): The Role of Soluble Factors and Cellular Components.Pharmaceutics · 2021Article
- Review
- The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method.International journal of molecular sciences · 2019Article
- The use of fat grafting and platelet-rich plasma for wound healing: A review of the current evidence.International wound journal · 2019Review
- Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Matrix- and plasma-derived peptides promote tissue-specific injury responses and wound healing in diabetic swine.Journal of translational medicine · 2016Article
- In vitro study of the role of thrombin in platelet rich plasma (PRP) preparation: utility for gel formation and impact in growth factors release.Journal of stem cells & regenerative medicine · 2016Article
- Recombinant Human Granulocyte Colony-Stimulating Factor Promotes Preinvasive and Invasive Estrogen Receptor-Positive Tumor Development in MMTV-erbB2 Mice.Journal of breast cancer · 2015Article
- Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.Clinical and experimental immunology · 2014Article
- Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo.Medical molecular morphology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe underlying rationale of platelet rich plasma (PRP) therapy is that an injection of concentrated PRP at the site of injury may promote tissue repair via cytokine release from platelets. The molecular mechanisms of PRP therapy in the skin wound healing process are not well understood at present, and would benefit from clarification.
methodsPRP was stimulated with angonists for 5 min, and cytokine profile analysis was performed. To investigate the wound healing activity of PRP, cell proliferation and migration analyses were performed in skin cells. The effects of PRP were analyzed on the expression and activity of matrix metalloproteinase (MMP)-1, -2, -9, and the activation of transcription factors.
resultsThrombin was found to be a strong stimulator of PRP activation to release growth factors and chemokines. PRP induced cell proliferation and migration in HUVECs, HaCaT cells, and HDFs, as well as MMP-1and MMP-9 expression in HaCaT cells, but PRP did not have a significant effect on the expression or activity of MMPs in HDFs. The transcription factors, including signal transducer and activator of transcription-3 (STAT-3) were found to be phosphorylated following PRP treatment in HaCaT cells.
conclusionIn this study, we have identified the cytokine profile of activated PRP after agonist stimulation. We have shown that PRP plays an active role in promoting the proliferation and migration of skin cells via the regulation of MMPs, and this may be applicable to the future development of PRP therapeutics to enhance skin wound healing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.