ArticleJournal of clinical neurology (Seoul, Korea)2011
High levels of remnant lipoprotein cholesterol is a risk factor for large artery atherosclerotic stroke.
Article in Journal of clinical neurology (Seoul, Korea), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Prognostic value of remnant cholesterol in patients with coronary heart disease: A systematic review and meta-analysis of cohort studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Association of residual lipoprotein-cholesterol and atherogenic index of plasma with in-hospital major adverse cardiovascular and cerebrovascular events after percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction.BMC cardiovascular disorders · 2026Article
- Roles of Nontraditional Lipid Parameters for Predicting Restenosis in Patients with Intracranial Atherosclerotic Stenosis After Endovascular Treatment.Clinical neuroradiology · 2024Article
- A Fishy Topic: VITAL, REDUCE-IT, STRENGTH, and Beyond: Putting Omega-3 Fatty Acids into Practice in 2021.Current cardiology reports · 2021Review
- Remnant Cholesterol is an Independent Predictor of New-Onset Diabetes: A Single-Center Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Developing Electron Microscopy Tools for Profiling Plasma Lipoproteins Using Methyl Cellulose Embedment, Machine Learning and Immunodetection of Apolipoprotein B and Apolipoprotein(a).International journal of molecular sciences · 2020Article
- Icosapent Ethyl: Niche Drug or for the Masses?Current cardiology reports · 2020Review
- Risk of cardiovascular events in patients with hypertriglyceridaemia: A review of real-world evidence.Diabetes, obesity & metabolism · 2020Review
- Effects of probiotics on the lipid profile: systematic review.Jornal vascular brasileiro · 2019Review
- The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Nonfasting Remnant Cholesterol in a Real World Population.Journal of lipids · 2018Article
- Remnant Lipoprotein Cholesterol and Incident Coronary Heart Disease: The Jackson Heart and Framingham Offspring Cohort Studies.Journal of the American Heart Association · 2016Observational
- A longitudinal study examining the effects of a season of American football on lipids and lipoproteins.Lipids in health and disease · 2015Article
- Energy replacement using glucose does not increase postprandial lipemia after moderate intensity exercise.Lipids in health and disease · 2014Article
- Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke.Annals of Indian Academy of Neurology · 2013Article
- Multimarker approach in discriminating patients with symptomatic and asymptomatic atherosclerotic carotid artery stenosis.Journal of clinical neurology (Seoul, Korea) · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRemnant lipoproteins (RLPs) are products of partially catabolized chylomicrons and very-low-density lipoprotein, from which some triglycerides have been removed. These particles are smaller and denser than the parent particles and are believed to be strongly atherogenic. We explored the association between RLP cholesterol (RLP-C) and ischemic stroke, including stroke subtypes.
methodsA cohort of 142 ischemic stroke patients (90 men and 52 women; age, 65.2±12.8 years, mean±SD) was enrolled; all had acute infarcts confirmed by diffusion-weighted MRI, and had fasting lipograms. A full stroke-related evaluation was conducted on each patient. An outpatient population of 88 subjects without a history of cerebrovascular or cardiovascular disease served as a control group. Serum RLP fractions were isolated using an immunoaffinity gel containing specific antiapolipoprotein (anti-apo)B-100 and anti-apoA-I antibodies. RLP-C values were considered to be high when they were in the highest quartile of all values in the study.
resultsHigh RLP-C values were more common in stroke patients than in control patients (31.0% vs. 14.8%, p=0.01), when 5.6 mg/dL (>75th percentile) was used as the cutoff value. Multivariable analyses indicated that RLP-C was a risk factor for stroke, with an odds ratio of 2.54 (p=0.045). The RLP-C level was higher in the large artery atherosclerosis subgroup (5.7±3.9 mg/dL) than in any other stroke subgroup (small vessel occlusion, 4.9±5.9 mg/dL; cardioembolism, 1.8±2.3 mg/dL; stroke of undetermined etiology, 3.1±2.9 mg/dL).
conclusionsWe have found an association between high RLP-C levels and ischemic stroke, and in particular large artery atherosclerotic stroke.
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Registered trials
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