ArticleThe Journal of nutrition2012
Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans.
Article in The Journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.Scientific reports · 2020Article
- Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention.Archives of medical science : AMS · 2019Article
- Article
- Case control feasibility study assessing the association between severity of coronary artery disease with Glutathione Peroxidase-1 (GPX-1) and GPX-1 polymorphism (Pro198Leu).BMC cardiovascular disorders · 2016Article
- Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.Nutrients · 2016Article
- Article
- Genome-wide association study of serum selenium concentrations.Nutrients · 2013Article
- Variation in selenoenzyme genes and prostate cancer risk and survival.The Prostate · 2013Article
- SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study.PloS one · 2013Article
- Serum selenium and skin diseases among Nigerians with human immunodeficiency virus/acquired immune deficiency syndrome.HIV/AIDS (Auckland, N.Z.) · 2013Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Previous studies suggest some effects of selenium on risk of several chronic diseases, which may be mediated through a small number of selenoenzymes with antioxidant properties. In this cross-sectional analysis of 195 participants from the Seattle Barrett's Esophagus Study who were free of esophageal cancer at the time of blood draw, we examined whether the number of the minor alleles in 26 tagging single nucleotide polymorphisms (SNP) of five selenoenzyme genes [i.e., glutathione peroxidase 1-4 (GPX1-4) and selenoprotein P (SEPP1)] was associated with activity of GPX1 in white blood cells and GPX3 in plasma, and concentrations of SEPP1 and markers of oxidative stress [malondialdehyde (MDA) and protein carbonyl content] in plasma. At the gene level, associations were observed between overall variation in GPX1 and GPX1 activity (P = 0.02) as well as between overall variation in GPX2 and SEPP1 concentrations (P = 0.03). By individual SNP, two variants in GPX1 (rs8179164 and rs1987628) showed a suggestive association with GPX1 activity (P = 0.10 and 0.08, respectively) and two GPX2 variants (rs4902346 and rs2071566) were associated with SEPP1 concentration (P = 0.004 and 0.002, respectively). Furthermore, two SNP in the SEPP1 gene (rs230813 and rs230819) were associated with MDA concentrations (P = 0.03 and 0.02, respectively). Overall, our study supports the hypothesis that common genetic variants in selenoenzymes affect their activity.
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