ArticleThe Journal of clinical endocrinology and metabolism2012
Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Body composition in anorexia nervosa: Meta-analysis and meta-regression of cross-sectional and longitudinal studies.The International journal of eating disorders · 2019Pooled it
- Brown Adipose Tissue (BAT) detection byEndocrine · 2018Pooled it
- Pharmacological treatment options for low Bone Mineral Density and secondary osteoporosis in Anorexia Nervosa: A systematic review of the literature.Journal of psychosomatic research · 2017Pooled it
- A systematic review and meta-analysis of the association between eating disorders and bone density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- State of the art systematic review of bone disease in anorexia nervosa.The International journal of eating disorders · 2016Pooled it
- Gender-specific effects of capsiate supplementation on body weight and bone mineral density: a randomized, double-blind, placebo-controlled study in slightly overweight women.Journal of endocrinological investigation · 2023Trial
- Tissue-specific insulin sensitivity in anorexia nervosa: A cross-sectional positron emission tomography (PET) study in female adults.Physiological reports · 2026Article
- DNA methylation changes in young female adolescents with anorexia nervosa : focus on puberty related genes.Journal of endocrinological investigation · 2026Article
- Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026Review
- Bone Modelling and Remodelling in Cold Environment.Biomolecules · 2025Review
- Different action of glucocorticoid receptor in adipose tissue remodelling to modulate energy homeostasis by chronic restraint stress.Lipids in health and disease · 2025Article
- Brown fat-specific mitoribosomal function is crucial for preventing cold exposure-induced bone loss.Cellular and molecular life sciences : CMLS · 2024Article
- The specificities, influencing factors, and medical implications of bone circadian rhythms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Fat as a Friend or Foe of the Bone.Current osteoporosis reports · 2024Review
- Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9.iScience · 2024Article
- The Role of Irisin throughout Women's Life Span.Biomedicines · 2023Review
- Similarities and differences regarding acute anorexia nervosa and semi-starvation: does behavioral thermoregulation play a central role?Frontiers in behavioral neuroscience · 2023Article
- Associations between bone mineral density, body composition and amenorrhoea in females with eating disorders: a systematic review and meta-analysis.Journal of eating disorders · 2022Review
- Article
- Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT.Histology and histopathology · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
contextAnorexia nervosa (AN) is associated with depletion of body fat, loss of bone mineral density (BMD), and impaired thermogenesis. Brown adipose tissue (BAT) is lower in obese individuals and decreases during aging. Recent studies have suggested a link between BAT and bone metabolism.
objectiveOur objective was to investigate the presence and quantity of BAT in patients with AN, recovered AN (AN-R), and normal-weight controls and to study the relationship between BAT and BMD and body composition and investigate hormonal predictors of BAT. DESIGN AND
settingThis was a cross-sectional study at a clinical research center. PATIENTS: Patients included 15 women: five with AN (mean age 30 ± 6.3 yr), five AN-R, and five healthy nonobese controls of comparable age.
main outcome measuresCold-activated BAT was determined by fluorodeoxyglucose-positron emission tomography/computed tomography. BMD of total-body, spine, and hip, fat and lean mass was determined by dual-energy x-ray absorptiometry. Single-slice magnetic resonance imaging at L4 was done for abdominal fat compartments, and preadipocyte factor-1 (Pref-1), T₃, and T₄ were measured.
resultsWithin the AN group, one of five; in the AN-R group, two of five; and in the healthy nonobese control group, four of five subjects were BAT positive. Subjects were divided into groups based on the presence (n = 7) or absence (n = 8) of BAT. Both groups were of comparable age and body mass index. Women with BAT had higher total-body BMD, higher T₃, and lower Pref-1 compared with women without BAT. There was a positive correlation between BAT and BMD that remained significant after controlling for disease status and body mass index.
conclusionYoung women with AN have low cold-activated BAT, which may be due to impaired BAT thermogenesis. Young women with BAT have higher BMD and lower Pref-1 compared with women without BAT, suggesting that BAT may be involved in the regulation of stem cell differentiation into the bone lineage at the expense of adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.