Evidence map›Paper›PMID 22259005›Full record

ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012

Improvement in PET myocardial perfusion image quality and quantification with flurpiridaz F 18.

Daniel S Berman, Guido Germano, Piotr J Slomka

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Incremental diagnostic value of artificial intelligence-derived coronary artery calcium inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Trial
  2. Subendocardial quantification enhances coronary artery disease detection inEuropean journal of nuclear medicine and molecular imaging · 2025
    Trial
  3. Rest/stress myocardial perfusion imaging by positron emission tomography withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  4. Review
  5. Motion correction to enhance absolute myocardial blood flow quantitation by PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  6. Review
  7. Article
  8. Development and validation of a phase analysis tool to measure interventricular mechanical dyssynchrony from gated SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  9. Article
  10. Article
  11. Imaging moving heart structures with PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  12. Article
  13. The role of PET quantification in cardiovascular imaging.Clinical and translational imaging · 2014
    Article
  14. Article
  15. Comparison of attenuation, dual-energy-window, and model-based scatter correction of low-count SPECT to 82Rb PET/CT quantified myocardial perfusion scores.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013
    Article
  16. State of the Art in Cardiac Hybrid Technology: PET/MR.Current cardiovascular imaging reports · 2013
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel S BermanCedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Daniel.Berman@cshs.org
Guido Germano
Piotr J Slomka

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rubidium-82 ((82)Rb), the currently commercially available radiotracer for positron emission tomography (PET) myocardial perfusion imaging (MPI), has led to wide availability of PET-MPI for stress-rest imaging. Compared to SPECT MPI, myocardial perfusion PET images have higher spatial and contrast resolution, are less affected by radiotracer scatter, benefit from more precise attenuation correction, and allow dynamic first pass imaging. In addition, PET imaging allows assessment of myocardial function at peak stress and measurement of absolute myocardial blood flow, thus providing critical data not available with SPECT imaging. Further enhancements of the high quality of PET perfusion images may be realized by technologies under development such as respiratory gating, combined respiratory, and ECG gating to generate "motion-frozen" cardiac images, automated patient motion correction software, and high-definition PET, which reduces distortions introduced by the circular geometry of the scanner. Early studies indicate that the experimental PET radiopharmaceutical flurpiridaz F 18 provides high-quality, high-resolution myocardial perfusion images that may enable improved clinical MPI, and has properties well suited to optimized performance by application of these quantitative analytic technologies.

Indexed as

PyridazinesCoronary Artery DiseaseHumansImage EnhancementMyocardial Perfusion ImagingPositron-Emission TomographyRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonBMS 747158-02PyridazinesRadiopharmaceuticals

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.