ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2012
Fracture risk in women with breast cancer: a population-based study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Osteoporotic Fractures of the Spine, Hip, and Other Locations after Adjuvant Endocrine Therapy with Aromatase Inhibitors in Breast Cancer Patients: a Meta-analysis.Journal of Korean medical science · 2020Pooled it
- The effect of denosumab in breast cancer patients receiving adjuvant aromatase inhibitors: 36-month results.Journal of bone and mineral metabolism · 2021Trial
- Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial.The Lancet. Oncology · 2014Trial
- Opportunistic Osteoporosis Screening in Breast Cancer Using AI-Derived Vertebral BMD from Routine CT: Validation Against QCT and Multivariable Diagnostic Modeling.Journal of clinical medicine · 2026Article
- Fracture risk among patients with cancer compared to individuals without cancer: a population-based study.British journal of cancer · 2023Article
- Is there an association between breast cancer and incident adhesive capsulitis of the shoulder? A retrospective cohort study from Germany.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Association between tamoxifen and incidence of osteoporosis in Korean patients with ductal carcinoma in situ.Frontiers in oncology · 2023Article
- Fracture risk in breast cancer: Does obesity have an effect? A scoping review.Journal of bone oncology · 2022Article
- Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data.Archives of osteoporosis · 2021Article
- The impact of arm lymphedema on healthcare utilization during long-term breast cancer survivorship: a population-based cohort study.Journal of cancer survivorship : research and practice · 2020Article
- Risk of Osteoporotic Fracture in Patients with Breast Cancer: Meta-Analysis.Journal of bone metabolism · 2020Article
- Increased risk of fractures in patients with polycystic ovary syndrome: a nationwide population-based retrospective cohort study.Journal of bone and mineral metabolism · 2018Article
- Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps.BMC cancer · 2018Article
- Incidence and predictors of osteoporotic fractures in patients with Barrett's oesophagus: a population-based nested case-control study.Alimentary pharmacology & therapeutics · 2017Article
- Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG.Journal of bone oncology · 2017Review
- Long-term effect of aromatase inhibitors on bone microarchitecture and macroarchitecture in non-osteoporotic postmenopausal women with breast cancer.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Observational
- Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study.British journal of cancer · 2016Article
- A 66-year-old woman with spontaneous rib fracture.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Article
- Minimal-trauma fracture in women with breast cancer surviving for at least 5 years from diagnosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Breast cancer survivors are at an increased risk for osteoporotic fractures not explained by lower BMD: a retrospective analysis.NPJ breast cancer · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A positive association has been reported between greater bone density and higher breast cancer risk, suggesting that these women could be at reduced risk of fracture. To estimate fracture risk among unselected community women with breast cancer and to systematically assess associations with various risk factors including breast cancer treatments, we conducted a population-based historical cohort study of 608 Olmsted County, MN, USA, women with invasive breast cancer first diagnosed in 1990 to 1999 (mean age 61.6 ± 14.8 years), who were followed for 5776 person-years. Altogether, 568 fractures were observed in 270 women (98 per 1000 person-years). Overall fracture risk was elevated 1.8-fold, but the absolute increase in risk was only 9%, and 56% of the women did not experience a fracture during follow-up. Excluding pathologic fractures (15%) and those found incidentally (24%), to allow for ascertainment bias, the standardized incidence ratio was 1.2 (95% confidence interval [CI] 0.99 to 1.3) for total fracture risk and 0.9 (95% CI 0.7 to 1.2) for osteoporotic fracture risk alone. Various breast cancer treatments were associated with an increased risk of fracture, but those associations were strongest for pathologic fractures, which were relatively more common among the women who were premenopausal when their breast cancer was diagnosed. Moreover, underlying clinical characteristics prompting different treatments may have been partially responsible for the associated fracture outcomes (indication bias). These data thus demonstrate that breast cancer patients in general are not at greatly increased risk of fracture but neither are they protected from fractures despite any determinants that breast cancer and high bone density may have in common.
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Registered trials
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