ArticleDigestive diseases and sciences2012
Anti-stress effects of transcutaneous electrical nerve stimulation (TENS) on colonic motility in rats.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS.Journal of neuroinflammation · 2025Review
- Comparative Analysis of High-Frequency and Low-Frequency Transcutaneous Electrical Stimulation of the Right Median Nerve in the Regression of Clinical and Neurophysiological Manifestations of Generalized Anxiety Disorder.Journal of clinical medicine · 2024Article
- Electroacupuncture in the treatment of IBS in rats: investigation of the mechanisms of CRHJournal of neurophysiology · 2023Article
- The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome.Frontiers in neuroscience · 2023Review
- Editorial: Sensory Stimulation and Oxytocin: Their Roles in Social Interaction and Health Promotion.Frontiers in psychology · 2022Article
- Wearable, Environmental, and Smartphone-Based Passive Sensing for Mental Health Monitoring.Frontiers in digital health · 2021Review
- Electro-Acupuncture Attenuates Chronic Stress ResponsesFrontiers in neuroscience · 2020Article
- Electroacupuncture: A New Approach for Improved Postoperative Sleep Quality After General Anesthesia.Nature and science of sleep · 2020Review
- Mechanism of Electroacupuncture on Postoperative Ileus Induced by Surgical Stress in Rats.Medical acupuncture · 2019Article
- A Review of Wearable Solutions for Physiological and Emotional Monitoring for Use by People with Autism Spectrum Disorder and Their Caregivers.Sensors (Basel, Switzerland) · 2018Review
- Electroacupuncture ameliorates abnormal defaecation and regulates corticotrophin-releasing factor in a rat model of stress.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2017Article
- Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis.Pain research & management · 2017Review
- The effect and mechanism of electroacupuncture at LI11 and ST37 on constipation in a rat model.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2016Article
- Article
- Acupuncture and regulation of gastrointestinal function.World journal of gastroenterology · 2015Review
- Inhibitory effect of TongXie-YaoFang formula on colonic contraction in rats.World journal of gastroenterology · 2015Article
- Acupuncture-moxibustion in treating irritable bowel syndrome: how does it work?World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisorders of colonic motility may contribute to symptoms in patients with irritable bowel syndrome (IBS), and stress is widely believed to play a major role in developing IBS. Stress increases corticotropin releasing factor (CRF) of the hypothalamus, resulting in acceleration of colonic transit in rodents. In contrast, hypothalamic oxytocin (OXT) has an anti-stress effect via inhibiting CRF expression and hypothalamic-pituitary-adrenal axis activity. Although transcutaneous electrical nerve stimulation (TENS) and acupuncture have been shown to have anti-stress effects, the mechanism of the beneficial effects remains unknown.
aimsWe tested the hypothesis that TENS upregulates hypothalamic OXT expression resulting in reduced CRF expression and restoration of colonic dysmotility in response to chronic stress.
methodsMale SD rats received different types of stressors for seven consecutive days (chronic heterotypic stress). TENS was applied to the bilateral hind limbs every other day before stress loading. Another group of rats did not receive TENS treatment.
resultsTENS significantly attenuated accelerated colonic transit induced by chronic heterotypic stress, which was antagonized by a central injection of an OXT antagonist. Immunohistochemical study showed that TENS increased OXT expression and decreased CRF expression at the paraventricular nucleus (PVN) following chronic heterotypic stress.
conclusionsIt is suggested that TENS upregulates hypothalamic OXT expression which acts as an anti-stressor agent and mediates restored colonic dysmotility following chronic stress. TENS may be useful to treat gastrointestinal symptoms associated with stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.