Evidence map›Paper›PMID 22258610›Full record

ReviewNature2012

The contribution of bone to whole-organism physiology.

Gérard Karsenty, Mathieu Ferron

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gérard KarsentyDepartment of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. gk2172@columbia.edu
Mathieu Ferron

Funding

Osteocalcin: the hormonal link between bone and reproductionR01HD065439 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KARSENTY, GERARD · 2010 to 2014
$1.6M
NICHD NIH HHS R01 HD065439
6 · The paper itself

Abstract

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

Indexed as

Physiological PhenomenaAnimalsAppetiteBone and BonesBone DiseasesEnergy MetabolismHumansLeptinOrgan SpecificityOsteocalcinLeptinOsteocalcin

Identifiers

PMID22258610
PMCPMC9047059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.