ArticleCardiorenal medicine2011
Hypertensive Cardiovascular and Renal Disease and Target Organ Damage: Lessons from Animal Models.
Article in Cardiorenal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- The effect of calcium and vitamin D supplements on blood pressure in postmenopausal women: myth or reality?Hypertension research : official journal of the Japanese Society of Hypertension · 2022Trial
- Transcriptomic Redox Dysregulation in a Rat Model of Metabolic Syndrome-Associated Kidney Injury.Antioxidants (Basel, Switzerland) · 2025Article
- Protective effects of melatonin on myocardial microvascular endothelial cell injury under hypertensive state by regulating Mst1.BMC cardiovascular disorders · 2023Article
- Article
- An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation.Cell death & disease · 2021Article
- Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes.Scientific reports · 2020Article
- Estrogen modulates the differential expression of cardiac myocyte chymase isoforms and diastolic function.Molecular and cellular biochemistry · 2019Article
- A PIECE OF MY MIND. A Wild Rotation.JAMA · 2016Article
- Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.Medicine · 2015Article
- Renal Effects and Underlying Molecular Mechanisms of Long-Term Salt Content Diets in Spontaneously Hypertensive Rats.PloS one · 2015Article
- Salt Loading Promotes Kidney Injury via Fibrosis in Young Female Ren2 Rats.Cardiorenal medicine · 2014Article
- Recent publications by ochsner authors.Ochsner journal · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This brief review discusses some aspects of hypertensive damage to the kidneys and cardiovascular system. A comparison of renal and cardiac manifestations of hypertensive disease between results of clinical and experimental studies was made, with a major focus on the possible role of salt and the renin-angiotensin system (RAS) in inducing target organ damage. Thus, some degree of renal impairment is often present in patients with essential hypertension, varying from microalbuminuria to end-stage renal disease, whereas in rats with spontaneous hypertension only slight renal damage is seen in old rats with little evidence of renal failure. Since renal damage in hypertensive rats is induced when they are exposed to increased salt intake, we suggested that salt may also account for kidney injury in hypertensive patients. Similarly, cardiac damage is aggravated in hypertensive human beings and rats when given salt excess. We further presented evidence that the RAS may mediate adverse cardiac and renal effects of excessive salt intake. Finally, we also discussed some aspects of the cardiovascular physiology in the giraffe, the only mammal that in comparison with the human being has extremely high pressure at the level of the heart and kidneys but no target organ damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.