ArticleEuropean radiology2012
Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 75 citations in OpenAlex.
- Use of diagnostic dynamic contrast-enhanced (DCE)-MRI for targeting of soft tissue tumour biopsies at 3T: preliminary results.European radiology · 2015Trial
- MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF.Medical oncology (Northwood, London, England) · 2014Trial
- Interobserver reproducibility of diffusion-weighted MRI in monitoring tumor response to neoadjuvant therapy in esophageal cancer.PloS one · 2014Trial
- Precise zonal diagnosis: multi-b-value DWI model reveals differential predictors of clinically significant prostate cancer in peripheral and transition zones.Insights into imaging · 2026Article
- Multi-b-value diffusion-weighted imaging-derived parameters for differentiating high-grade serous ovarian carcinoma from other epithelial ovarian cancers.Japanese journal of radiology · 2025Article
- Nomogram for predicting tumor-stroma ratio in pancreatic ductal adenocarcinoma using dual-energy computed tomography.BMC medical imaging · 2025Article
- Association between diffusion-weighted imaging and tumor matrix in liver cancer: a cross-sectional study.Translational cancer research · 2025Article
- Assessment of the imaging quality and heterogeneous predictive value of readout-segmented echo planar imaging for diffusion-weighted rectal MRI.Frontiers in oncology · 2025Article
- Novel Advances in Qualitative Diagnostic Imaging for Decision Making in Multidisciplinary Treatment for Advanced Esophageal Cancer.Journal of clinical medicine · 2024Review
- Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors.European radiology · 2023Article
- Ultra-high b-Value DWI in predicting progression risk of locally advanced rectal cancer: a comparative study with routine DWI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Prognostic value of multi b-value DWI in patients with locally advanced rectal cancer.European radiology · 2023Article
- Muscle-invasive bladder cancer: pretreatment prediction of response to neoadjuvant chemotherapy with diffusion-weighted MR imaging.Abdominal radiology (New York) · 2022Article
- Response Prediction to Concurrent Chemoradiotherapy in Esophageal Squamous Cell Carcinoma Using Delta-Radiomics Based on Sequential Whole-Tumor ADC Map.Frontiers in oncology · 2022Article
- Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Histogram Analysis of Diffusion-Weighted MR Imaging as a Biomarker to Predict Survival of Surgically Treated Colorectal Cancer Patients.Digestive diseases and sciences · 2021Article
- Associations between apparent diffusion coefficient values and histopathological tissue alterations in myopathies.Brain and behavior · 2020Article
- The value of multiparametric histogram features based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for the differential diagnosis of liver lesions.Annals of translational medicine · 2020Article
- Diagnostic performance of diffusion-weighted magnetic resonance imaging in assessing lymph node metastasis of esophageal cancer compared with PET.Esophagus : official journal of the Japan Esophageal Society · 2020Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBecause diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis.
methodsSeventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.
resultsThe ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen (r = -0.729, P = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, P = 0.026).
conclusionOur results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer. KEY POINTS: • Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen • There is also negative correlation between ADCs and vascular endothelial growth factor • ADC values may contribute to the treatment of oesophageal cancer.
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