ArticleMolecules (Basel, Switzerland)2012
Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Vinegar-processed frankincense extracts alleviate colorectal cancer by butyric acid mediating M1 tumor-associated macrophage pyroptosis.Chinese medicine · 2025Article
- Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid fromMolecules (Basel, Switzerland) · 2022Article
- Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review.Molecules (Basel, Switzerland) · 2021Review
- The Analgesic Properties ofMolecules (Basel, Switzerland) · 2021Review
- Rapid Quality Identification of Decoction Pieces of Crude and ProcessedJournal of analytical methods in chemistry · 2021Article
- Processing and Compatibility ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Optimization of the extraction and purification ofBMC chemistry · 2020Article
- The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients.Pharmaceutical biology · 2020Review
- The Effects of Vinegar Processing on the Changes in the Physical Properties of Frankincense Related to the Absorption of the Main Boswellic Acids.Molecules (Basel, Switzerland) · 2019Article
- Preliminary study to evaluate the phytochemicals and physiochemical properties in red and black date's vinegar.Food science & nutrition · 2019Article
- Effects of processing adjuvants on traditional Chinese herbs.Journal of food and drug analysis · 2018Review
- Bioactive Compounds in Cornelian Cherry Vinegars.Molecules (Basel, Switzerland) · 2018Article
- Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC-MS/MS Method and Its Application in Pharmacokinetic Study.Molecules (Basel, Switzerland) · 2016Article
- Influence of vinegar and wine processing on the alkaloid content and composition of the traditional Chinese medicine Corydalis Rhizoma (Yanhusuo).Molecules (Basel, Switzerland) · 2014Article
- Review of Scientific Evidence of Medicinal Convoy Plants in Traditional Persian Medicine.Pharmacognosy reviewsReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Vinegar and wine processing of medicinal plants are two traditional pharmaceutical techniques which have been used for thousands of years in China. Tetrahydropalmatine (THP), dehydrocorydaline (DHC) and protopine are three major bioactive molecules in Rhizoma Corydalis. In this study, a simple and reliable HPLC method was developed for simultaneous analysis of THP, DHC and protopine in rat tissues after gastric gavage administration of Rhizoma Corydalis. The validated HPLC method was successfully applied to investigate the effect of wine and vinegar processing on the compounds' distribution in rat tissues. Our results showed that processing mainly affect the T(max) and mean residence time (MRT) of the molecules without changing their C(max) and AUC(0-24)( )(h) Vinegar processing significantly increased the T(max) of DHC in heart, kidney, cerebrum, cerebrellum, brain stem and striatum and prolonged the T(max) of protopine in brain. No significant changes were observed on the T(max) of THP in rat tissues after vinegar processing. Wine processing reduced the T(max) of protopine and DHC in liver and spleen and T(max) of protopine in lung, but increased the T(max) of THP in all the rat tissues examined. To our knowledge, this is the first report on the effects of processing on the tissue distribution of the bioactive molecules from Rhizoma Corydalis.
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