ArticleThe Journal of membrane biology2012
Ancient origin of four-domain voltage-gated Na+ channels predates the divergence of animals and fungi.
Article in The Journal of membrane biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.Nature reviews. Neuroscience · 2026Review
- Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals.Biochemical and biophysical research communications · 2020Article
- Inherency of Form and Function in Animal Development and Evolution.Frontiers in physiology · 2019Review
- Diversity and evolution of four-domain voltage-gated cation channels of eukaryotes and their ancestral functional determinants.Scientific reports · 2018Article
- Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations.Frontiers in physiology · 2018Article
- From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium Channels.Current topics in membranes · 2016Article
- Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora.Frontiers in physiology · 2016Article
- Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view.Cell calcium · 2015Review
- Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels.Frontiers in physiology · 2015Review
- Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Science signaling · 2014Article
- Phylogenomics demonstrates that breviate flagellates are related to opisthokonts and apusomonads.Proceedings. Biological sciences · 2013Article
- Phylogeny unites animal sodium leak channels with fungal calcium channels in an ancient, voltage-insensitive clade.Molecular biology and evolution · 2012Article
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Abstract
The four-domain voltage-gated Na(+) channels are believed to have arisen in multicellular animals, possibly during the evolution of the nervous system. Recent genomic studies reveal that many ion channels, including Na(+) channels and Ca(2+) channels previously thought to be restricted to animals, can be traced back to one of the unicellular ancestors of animals, Monosiga brevicollis. The eukaryotic supergroup Opisthokonta contains animals, fungi, and a diverse group of their unicellular relatives including M. brevicollis. Here, we demonstrate the presence of a putative voltage-gated Na(+) channel homolog (TtrNa(V)) in the apusozoan protist Thecamonas trahens, which belongs to the unicellular sister group to Opisthokonta. TtrNa(V) displays a unique selectivity motif distinct from most animal voltage-gated Na(+) channels. The identification of TtrNa(V) suggests that voltage-gated Na(+) channels might have evolved before the divergence of animals and fungi. Furthermore, our analyses reveal that Na(V) channels have been lost independently in the amoeboid holozoan Capsaspora owczarzaki of the animal lineage and in several basal fungi. These findings provide novel insights into the evolution of four-domain voltage-gated ion channels, ion selectivity, and membrane excitability in the Opisthokonta lineage.
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